Determination of protein allergenicity: studies in mice

Toxicology Letters
Rebecca J Dearman, Ian Kimber

Abstract

There is a need to identify and characterize the allergenic potential of novel proteins introduced into genetically-modified crop plants. Although several approaches have already been described, none of these measures directly the ability of proteins to cause allergic sensitization. For this reason there has been a growing interest in the development of suitable animal models. This article describes experience to date with a method based upon assessment of serological (IgG and IgE antibody) responses induced in BALB/c strain mice by proteins. Comparisons have been made between intraperitoneal (i.p.) administration and exposure by gavage using both allergenic and non-allergenic proteins. The available data indicate that responses provoked by i.p. exposure permit the identification of proteins that have the inherent potential to induce IgE antibody production and allergic sensitization. Moreover, this approach also provides a rank order of proteins with respect to allergenic potency that apparently reflects what is known of their relative sensitizing activity in humans. By comparison, oral exposure of mice by gavage is somewhat less sensitive. On this basis it is proposed that the inherent sensitizing potential of novel proteins ...Continue Reading

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Citations

Apr 5, 2003·Toxicology Letters·Ian KimberRebecca J Dearman
Mar 18, 2011·Journal of Agricultural and Food Chemistry·Shen-Shih ChiangTzu-Ming Pan
Apr 15, 2003·The Proceedings of the Nutrition Society·Ian Kimber, Rebecca J Dearman
Nov 30, 2005·The Proceedings of the Nutrition Society·Rebecca J Dearman, Ian Kimber
Nov 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christal C Bowman, Maryjane K Selgrade
Feb 8, 2003·Environmental Health Perspectives·Ian KimberRebecca J Dearman
Jun 27, 2003·Environmental Health Perspectives·Ian KimberRicki M Helm
Feb 3, 2009·Regulatory Toxicology and Pharmacology : RTP·Samuel B Lehrer, Scott McClain
Sep 16, 2008·Veterinary Parasitology·Maria Angeles Gòmez-MoralesEdoardo Pozio
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DearmanI Kimber
Dec 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X LiuJ X Liu
Jun 1, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P SotkovskýL Tučková
May 5, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A KönigJ M Wal
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May 6, 2004·Current Opinion in Allergy and Clinical Immunology·Léon M J KnippelsAndré H Penninks
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