PMID: 8953260Nov 1, 1996Paper

Determination of pulmonary mean transit time and cardiac output using a one-dimensional model

Bulletin of Mathematical Biology
C Le Sech, A Capderou

Abstract

In this work, we show that a one-dimensional model of the blood flow across the lungs can reproduce the evolution of a bolus versus the time. Solving the differential equation governing the bolus concentration in the framework of this model, we determine the solution which fulfills Gaussian initial boundary conditions. An effective parameter related to the ratio of a diffusion coefficient to the square of the mean speed of the flow is defined. The determination of its numerical values following a semi-empirical approach enables us to know accurately the mean transit time and the cardiac output. The results have been compared to other methods, and were found in good agreement. Such an approach could be of interest in all studies where the knowledge of flow--including micro-circulation--is needed.

References

Apr 1, 1992·Computers and Biomedical Research, an International Journal·R P Beyer
Dec 1, 1990·European Heart Journal·F M Fouad-Tarazi, W J MacIntyre
Sep 1, 1988·Journal of Applied Physiology·J C HoggB Wiggs
Apr 1, 1988·Computers and Biomedical Research, an International Journal·J B BassingthwaighteA A Goldstein
Jul 1, 1969·Journal of Applied Physiology·T J Knopp, J B Bassingthwaighte
Mar 1, 1970·The Bulletin of Mathematical Biophysics·K H Norwich, S Zelin
May 1, 1970·Circulation Research·A MaseriK L Zierler
Apr 1, 1966·Circulation Research·J B BassingthwaighteE H Wood
Mar 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C A DawsonT S Hakim
Mar 1, 1995·Journal of Applied Physiology·S H AudiD L Roerig
Mar 1, 1994·Journal of Applied Physiology·M L LewisC Giuntini
Apr 1, 1994·Journal of Applied Physiology·R G PressonW W Wagner
May 1, 1961·Circulation Research·F S GOTTW H PRITCHARD
Jun 1, 1964·Circulation Research·H K THOMPSONH D MCINTOSH

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Citations

Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·M BoosG M Bongartz
Aug 28, 2009·Journal of Magnetic Resonance Imaging : JMRI·Jeff L ZhangVivian S Lee

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