Determination of reference values for glucose tolerance, insulin tolerance, and insulin sensitivity tests in clinically normal cats

American Journal of Veterinary Research
D J AppletonG D Sunvold

Abstract

To determine reference values and test variability for glucose tolerance tests (GTT), insulin tolerance tests (ITT), and insulin sensitivity tests (IST) in cats. 32 clinically normal cats. GTT, ITT, and IST were performed on consecutive days. Tolerance intervals (ie, reference values) were calculated as means +/- 2.397 SD for plasma glucose and insulin concentrations, half-life of glucose (T1/2 glucose), rate constants for glucose disappearance (Kglucose and Kitt), and insulin sensitivity index (Si). Tests were repeated after 6 weeks in 8 cats to determine test variability. Reference values for T1/2glucose, Kglucose, and fasting plasma glucose and insulin concentrations during GTT were 45 to 74 minutes, 0.93 to 1.54 %/min, 37 to 104 mg/dl, and 2.8 to 20.6 microU/ml, respectively. Mean values did not differ between the 2 tests. Coefficients of variation for T1/2glucose, Kglucose, and fasting plasma glucose and insulin concentrations were 20, 20, 11, and 23%, respectively. Reference values for Kitt were 1.14 to 7.3%/min, and for SI were 0.57 to 10.99 x 10(4) min/microU/ml. Mean values did not differ between the 2 tests performed 6 weeks apart. Coefficients of variation for Kitt and SI were 60 and 47%, respectively. GTT, ITT, and ...Continue Reading

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Citations

Jun 1, 2005·Journal of Feline Medicine and Surgery·D J AppletonG D Sunvold
May 25, 2002·Journal of Feline Medicine and Surgery·D J AppletonG D Sunvold
Jan 3, 2006·Diabetes Technology & Therapeutics·Charles E WiedmeyerAmy E DeClue
Jun 29, 2006·ILAR Journal·Michael S Henson, Timothy D O'Brien
Nov 6, 2012·Veterinary Clinical Pathology·Emma M StrageInger Lilliehöök
Jun 4, 2011·The Journal of Veterinary Medical Science·Kyoji YasudaHitoshi Kitagawa
Oct 14, 2003·Journal of the American Veterinary Medical Association·Charles E WiedmeyerRichard L Meadows
Jul 23, 2013·Journal of Veterinary Internal Medicine·H A FarrowG D Sunvold
Sep 8, 2011·Journal of Animal Physiology and Animal Nutrition·A VerbruggheG P J Janssens
Jan 4, 2005·The Veterinary Clinics of North America. Small Animal Practice·Jacquie S Rand, Rhett D Marshall
May 7, 2015·Journal of Veterinary Internal Medicine·C J ScudderS J M Niessen
Aug 31, 2016·Domestic Animal Endocrinology·M K Reeve-JohnsonD Vankan
Feb 7, 2017·Journal of Feline Medicine and Surgery·Mia K Reeve-JohnsonJohn M Morton
Jul 10, 2012·Journal of Diabetes Science and Technology·Margarethe Hoenig
Sep 3, 2009·Journal of the American Animal Hospital Association·Andrew D LoweDavid J Schaeffer
Nov 16, 2017·Veterinary Sciences·Adronie Verbrugghe, Myriam Hesta

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