Determination of sarin, soman and their hydrolysis products in soil by packed capillary liquid chromatography-electrospray mass spectrometry

Journal of Chromatography. a
P A D'AgostinoL R Provost

Abstract

An analytical method based on aqueous ultrasonic extraction and packed capillary liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) analysis was developed and compared to an existing gas chromatography(GC)-MS based method for the determination of sarin, soman and their hydrolysis products in contaminated soil. Three soils, a red clay, a tan sandy clay and a brown sandy clay loam, were spiked with sarin and soman and their initial hydrolysis products, isopropyl methylphosphonic acid and pinacolyl methylphosphonic acid, at the 10 microg/g level to assess recovery efficiency. Recovery of sarin and soman from the aqueous soil extracts was comparable to the existing analytical method, with a significant improvement in recovery being demonstrated for the chemical warfare agent hydrolysis products. Sarin and soman were recovered in the 20-90% range from the three soil types with aqueous extraction, while the hydrolysis products of these chemical warfare agents were extracted with recoveries in excess of 80%. The developed soil extraction and analysis method appears to be an attractive alternative to the GC-MS based method, since aqueous extracts containing chemical warfare agent hydrolysis products may be analysed direct...Continue Reading

References

Mar 23, 1990·Journal of Chromatography·Z WitkiewiczJ Szulc

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Citations

Jul 27, 2001·Journal of Mass Spectrometry : JMS
Jan 18, 2006·Journal of the American Society for Mass Spectrometry·Wes E SteinerVincent M McHugh
Sep 6, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mieko Kataoka, Yasuo Seto
Sep 25, 2007·Dental Clinics of North America·Melissa NaimanPeter R Valentin
Mar 28, 2003·Rapid Communications in Mass Spectrometry : RCM·T Jagadeshwar ReddyM Vairamani
Apr 22, 2004·European Journal of Mass Spectrometry·Paul A D'AgostinoClaude L Chenier
Jun 23, 2006·Rapid Communications in Mass Spectrometry : RCM·V V S LakshmiM Vairamani
Aug 23, 2006·Journal of Separation Science·Barbora PapouskováKarel Lemr
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Tjerk J H BuetersMeindert Danhof
Oct 20, 2006·The Journal of Physical Chemistry. B·A MichalkovaJ Leszczynski

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