Determination of selected sulfonamide antibiotics and trimethoprim in manure by electrospray and atmospheric pressure chemical ionization tandem mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Thomas PfeiferMichael Spiteller

Abstract

A method for the determination of sulfonamides and trimethoprim in the complex matrix liquid manure has been developed using reversed-phase liquid chromatography and atmospheric pressure chemical ionization (APCI) tandem mass spectrometry. A comparison was made between electrospray and atmospheric pressure chemical ionization. APCI proved to be more robust and less sensitive to matrix effects. High-performance liquid chromatographic (HPLC) separation of the analytes was achieved in less than 7 min. The compounds were extracted with ethyl acetate and the extracts were cleaned up by solid-phase extraction on an aminopropyl column. Recoveries were not dependent on the concentration level. The mean recoveries were as follows: trimethoprim 79.0%, sulfadiazine 80.5%, N(4)-acetylsulfadiazine 91.0%, sulfamerazine 78.6%, sulfadimidine 77.2% and sulfamethoxazole 82.8%. Linearity was established over a concentration range of 5 to 5000 microg/kg with correlation coefficients greater than 0.99. The method had a limit of quantitation (LOQ) of 5 microg/kg manure.

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Citations

Feb 18, 2006·Analytical and Bioanalytical Chemistry·Anne Marie Jacobsen, Bent Halling-Sørensen
Jul 10, 2007·Analytical and Bioanalytical Chemistry·Marc LamshöftMichael Spiteller
Aug 16, 2005·Journal of the American Society for Mass Spectrometry·Thomas PfeiferRegine Fuchs
Sep 22, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Carmen Lidia ChitescuAlida Adriana Maria Stolker
Feb 18, 2006·Archives of Environmental Contamination and Toxicology·M P SchlüsenerK Bester
May 23, 2012·Talanta·Bojidarka B Ivanova, Michael Spiteller
Sep 15, 2005·Journal of Separation Science·Adela KrivohlavekFranjo Plavic-Plavsic
May 29, 2003·Rapid Communications in Mass Spectrometry : RCM·Katerina KlagkouG John Langley
Oct 31, 2003·Rapid Communications in Mass Spectrometry : RCM·Katerina KlagkouG John Langley
Jan 27, 2012·Rapid Communications in Mass Spectrometry : RCM·Samantha J Barry, Jean-Claude Wolff
Aug 19, 2005·Journal of Chromatography. a·Anke a GöbelThomas A Ternes
Feb 13, 2007·Environmental Pollution·Elena Martínez-CarballoOliver Gans
Feb 8, 2006·Environmental Pollution·Michael P Schlüsener, Kai Bester
Jun 9, 2012·The Analyst·Bojidarka Ivanova, Michael Spiteller
Dec 28, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·María Ramos PayánManuel Callejón Mochón
Jun 9, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chunna GuoYahong Liu
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Jul 12, 2002·Journal of Mass Spectrometry : JMS
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Apr 23, 2003·Analytical and Bioanalytical Chemistry·Michael P SchlüsenerMichael Spiteller
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