Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS

The Analyst
David P BishopPhilip A Doble

Abstract

Gadolinium (Gd)-based magnetic resonance imaging (MRI) contrasting agents interfere with the determination of selenium (Se) when analysed by single quadrupole inductively coupled plasma-mass spectrometry (ICP-MS). This paper demonstrates that an ICP-triple quadrupole-MS (ICP-QQQ-MS) with oxygen mass shift overcomes Gd(++) interference on Se(+) and mitigates typically encountered matrix and spectral based interferences. Normal human serum was diluted in a solution containing isopropanol, EDTA, NH4OH and Triton X-100. Samples were unspiked (control) serum; serum spiked with 0.127 μmol L(-1) Se or 127 μmol L(-1) Gd; and serum spiked with both 0.127 μmol L(-1) Se and 127 μmol L(-1) Gd. Consideration of collision/reaction gases and conditions for interference mitigation included helium (He); a 'low' and 'high' hydrogen (H2) flow, and oxygen (O2). The instrument tune for O2 was optimised for effective elimination of interferences via a mass shift reaction of Se(+) to SeO(+). The ICP-QQQ-MS was capable of detecting trace (>9.34 nmol L(-1)) levels of Se in serum in the presence of Gd in our simulated post-MRI serum sample. The multi-tune capabilities of the ICP-QQQ-MS may be adapted to eliminate other specific isobaric interferences th...Continue Reading

References

Jan 1, 1983·The American Journal of Clinical Nutrition·T D Shultz, J E Leklem
Feb 1, 1993·The American Journal of Clinical Nutrition·A T Diplock
Jun 1, 1997·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·M RükgauerJ D Kruse-Jarres
Aug 30, 2000·Lancet·M P Rayman
Aug 31, 2002·Endocrine Reviews·Pekka CollinJorma Salmi
May 31, 2003·Science·Gregory V KryukovVadim N Gladyshev
Feb 27, 2004·European Journal of Clinical Nutrition·C D Thomson
Jan 26, 2007·European Journal of Clinical Nutrition·G A JacobsonG M Peterson
Jul 10, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Judith Burri, Max Haldimann
Oct 31, 2007·International Journal of Public Health·Jürgen Barth
Oct 28, 2008·Biological Trace Element Research·Sophia LetsiouChristodoulos Stefanadis
Apr 29, 2009·Cellular and Molecular Life Sciences : CMLS·M A Reeves, P R Hoffmann
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Silvio Aime, Peter Caravan
Sep 4, 2010·Antioxidants & Redox Signaling·Susan J Fairweather-TaitRachel Hurst
Apr 2, 2011·Analytical and Bioanalytical Chemistry·Isabel Lopez HerasYolanda Madrid
Aug 13, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yasumi AnanYasumitsu Ogra
Jan 15, 2014·Analytica Chimica Acta·Lieve BalcaenFrank Vanhaecke
Feb 4, 2014·Trends in Biochemical Sciences·Dolph L HatfieldVadim N Gladyshev
May 3, 2014·The New England Journal of Medicine·Joseph Loscalzo
Jan 23, 2015·Journal of Analytical Atomic Spectrometry·Brian JacksonJenny Nelson

❮ Previous
Next ❯

Citations

Oct 30, 2019·Metallomics : Integrated Biometal Science·Barbara R CardosoBlaine R Roberts
May 5, 2020·Critical Reviews in Food Science and Nutrition·Krystyna Pyrzynska, Aleksandra Sentkowska
Dec 23, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Peter Heitland, Helmut D Köster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.