Determination of sibship in any two persons

Transfusion
Robert E WenkFrancis A Chiafari

Abstract

Parentage testing laboratories may be asked to provide genetic evidence that two persons are or are not related, when no other relatives are available for study. Simple methods using autosomal, codominant, unlinked genetic systems can determine if two people are blood relatives (e.g., siblings). The odds ratios (full sibship index) of true sibling pairs were determined from two-child paternity cases and compared with regionally and racially matched control pairs of unrelated children. The sharing of two, one, or no alleles was observed in pairs of children at three independent, polymorphic VNTR (variable number of tandem repeat) sequences loci. The sibship index was calculated as (the chance that an observation would occur if two children were siblings) divided by (the chance that it would occur if the two were unrelated). Sibship indices and the frequencies of shared alleles were determined for 20 sibling pairs and 20 control pairs. Sibship index values were less than 1 in all 20 pairs of unrelated children. Sibship index values were greater than 100 in nine pairs of siblings (45%), between 10 and 100 in five pairs (25%), between 1 and 10 in four pairs (20%), and less than 1 in two pairs (10%). Siblings shared two alleles in 1...Continue Reading

Citations

Jun 12, 2002·International Journal of Legal Medicine·Wing K FungDart-man Wong
Jan 25, 2000·Transfusion·R E Wenk, F A Chiafari
Aug 23, 2012·Croatian Medical Journal·James Chun-I LeeHsing-Mei Hsieh
Apr 9, 2015·Legal Medicine·Tomonori TamuraTakashi Nakamura
Nov 22, 2015·International Journal of Legal Medicine·Stefania TurrinaDomenico De Leo
Jan 30, 2013·Journal of Forensic and Legal Medicine·Tomonori TamuraItaru Sato
Sep 23, 2010·Human Immunology·Christina E M VoorterMarcel G J Tilanus
May 31, 2008·Journal of Forensic and Legal Medicine·Chang En Pu, Adrian Linacre
Jul 1, 2008·Journal of Forensic and Legal Medicine·Chang En Pu, Adrian Linacre
Mar 9, 2005·Transfusion·Robert E WenkTerry Houtz
Apr 11, 2012·Transfusion·Robert E Wenk, Alison Shao
Oct 19, 2010·Journal of Forensic Sciences·Robert E Wenk
Aug 22, 2015·International Journal of Legal Medicine·Nicole von Wurmb-SchwarkMicaela Poetsch
Dec 14, 2011·Molecular Biology Reports·Jasmin MusanovicDamir Marjanovic
Nov 20, 2016·Journal of Forensic Sciences·Jian Huang, YuSong Huang
Feb 4, 2003·Archives of Pathology & Laboratory Medicine·Robert E Wenk
Jul 28, 2021·Forensic Science International. Genetics·Noreen KarimRobert H Rice

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