PMID: 3573825May 1, 1987Paper

Determination of silica-purified plasma calcitonin for the detection and management of medullary thyroid carcinoma: comparison of two provocative tests

Mayo Clinic Proceedings
H GharibH Heath

Abstract

Radioimmunoassays for human calcitonin in whole plasma are limited in sensitivity and specificity; basal values of calcitonin are often undetectable in normal plasma, and nonspecific increases are occasionally found in seemingly healthy persons. We avoided these problems by applying a silica-cartridge extraction-concentration technique for calcitonin assay, and the effectiveness of two calcitonin stimulation tests in healthy volunteers and patients with medullary thyroid carcinoma was compared. The radioimmunoassay was improved by using a new antiserum and a sequential incubation procedure that reduced the previously used sample-volume requirement and incubation period substantially. This method was used to measure mean basal plasma levels of calcitonin (+/-SD) in 45 normal men (8.2 +/- 5 pg/ml) and 47 normal women (4.8 +/- 4 pg/ml) (P less than 0.001). Calcium infusions (2 mg/kg over 5 minutes) in 18 normal men and 37 normal women yielded a significantly greater secretory response than did pentagastrin (0.5 micrograms/kg as a bolus). Among 12 patients with medullary thyroid carcinoma, pentagastrin seemed to be a better secretagogue than calcium (P less than 0.001). We recommend routine measurement of plasma silica-extractable ...Continue Reading

References

Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J F HennessyD A Ontjes
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J G ParthemoreL J Deftos
Nov 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J J Body, H Heath

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Citations

Jul 1, 1997·The American Journal of Medicine·H M HeshmatiG W Sizemore
Dec 17, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Giuseppe CostanteSebastiano Filetti
Feb 1, 1997·Thyroid : Official Journal of the American Thyroid Association·G HernándezJ Mesa
Jan 1, 2006·Hereditary Cancer in Clinical Practice·Jan Willem de GrootJohn Tm Plukker
Oct 1, 1994·Mayo Clinic Proceedings·M W YocumH Gharib
Dec 1, 1993·Mayo Clinic Proceedings·P C Kao, H Gharib
Jul 1, 1990·Trends in Endocrinology and Metabolism : TEM·W B Carter, H Heath
Mar 1, 1991·The American Journal of Medicine·E V AdlinB J Channick
Aug 9, 2006·European Journal of Gastroenterology & Hepatology·Laurent WuilmetGuillaume Cadiot
Jun 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Patricia DoyleMarkus Luster
Jan 12, 2020·Endocrine·Giuseppe Costante, Domenico Meringolo
Dec 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Carla ColomboLaura Fugazzola
Oct 17, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Farhad ZangenehPai Chih Kao
Sep 18, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D Giuffrida, H Gharib
Jun 22, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Mara BăetuCorin Badiu

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