Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Kai ZhangWilliam Limm

Abstract

A pressurised solvent extraction procedure coupled with a gas chromatography-mass spectrometry-selective ion monitoring (GC-MS-SIM) method was developed to determine three cyclic siloxanes, octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), dodecamethylcyclohexasiloxane (D6) and three linear siloxanes, octamethyltrisiloxane (L3), decamethyltetrasiloxane (L4), dodecamethylpentasiloxane (L5), in silicone products. Additionally, two different extraction methods were developed to measure these siloxanes migrating into milk, infant formula and liquid simulants (50 and 95% ethanol in water). The limits of quantification (LOQs) of the six siloxanes ranged from 6 ng/g (L3) to 15 ng/g (D6). Silicone nipples and silicone bakewares were extracted using pressurised solvent extraction (PSE) and analysed using the GC-MS-SIM method. No linear siloxanes were detected in the silicone nipple samples analysed. The three cyclic siloxanes (D4, D5 and D6) were detected in all silicone nipple samples with concentrations ranging from 0.5 to 269 µg/g. In the bakeware samples, except for L3, the other five siloxanes were detected with concentrations ranging from 0.2 µg/g (L4) to 7030 µg/g (D6). To investigate the potential migration o...Continue Reading

References

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Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ruediger HellingThomas Joachim Simat
Nov 6, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ruediger HellingThomas Joachim Simat

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Citations

Nov 19, 2015·Regulatory Toxicology and Pharmacology : RTP·Allison FranzenKathy Plotzke
Nov 26, 2015·International Journal of Environmental Research and Public Health·Dongoh LeeEui-Bae Jeung
Nov 28, 2020·Environmental Science and Pollution Research International·Jiali ChengJiazheng Sun
Dec 17, 2014·Chemical Reviews·Christoph Rücker, Klaus Kümmerer

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Methods Mentioned

BETA
atomic absorption spectroscopy
nuclear magnetic resonance

Software Mentioned

ChemStation E

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