Determination of soluble ICAM-1 and TNFalphaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis

Arquivos de neuro-psiquiatria
S V Alves-LeonT Quírico-Santos

Abstract

Cytokines and adhesion molecules have been implicated in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. In this study we analyzed intrathecal (CSF) and serum levels of soluble intercellular adhesion molecule (ICAM-1) and TNFalphaR (60kD) from 20 patients with clinically definite MS during acute relapse or stable disease. Comparing to control groups of healthy individuals and patients with intervertebral herniated disc, MS patients showed increased levels (p< 0.001) of sICAM-1 and TNFalphaR in both serum and CSF samples. Regardless stage of disease there was no significant difference in the levels of sICAM-1 during acute relapse (657+/-124.9 ng/ml) or remission (627+/-36.2 ng/ml). A steady increase of TNFalphaR (60kD) in both serum and CSF, indicate the existence of a continuous inflammatory process within the brain tissue of MS patients despite absence of clinical signs of disease activity.

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Citations

Jan 27, 2009·Clinical Neurology and Neurosurgery·Marilza Campos-de-MagalhãesSoniza Vieira Alves-Leon
Dec 13, 2005·Experimental Neurology·J MiklossyP L McGeer
May 12, 2009·Neurobiology of Disease·Hayrettin TumaniUNKNOWN BioMS Study Group
Jan 10, 2006·Arquivos de neuro-psiquiatria·Carlos Otávio BrandãoLeonilda Maria Barbosa Santos
May 11, 2007·Acta Neurologica Scandinavica·S V Alves-LeonO Fernández y Fernandez

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