Determination of strain energy function for arterial elastin: Experiments using histology and mechanical tests

Journal of Biomechanics
Namrata GundiahLisa A Pruitt

Abstract

The long-range reversible deformation of vertebrate arteries is primarily mediated by elastin networks that endure several million deformation cycles without appreciable fatigue. To determine how elastin contributes to the composite arterial properties, we studied the three-dimensional microstructure and biomechanics of isolated elastin. We initially estimated the sensitivity of these studies by comparing two elastin isolation protocols, autoclaving and alkali-extraction, and measured their effect on isolated elastin using uniaxial tests and histology. These studies show that autoclaved tissues have a trend for higher modulus (900.79+/-678.02 kPa) than alkali-extracted samples (417.74+/-162.23 kPa)albeit with higher collagen-proteoglycan impurities, and (2) greater optical density (78.6+/-9.1%) than alkali-extracted groups (46.2+/-5.9%), suggesting that autoclaving is superior to alkali-extraction for biomechanical tests on elastin. Using these data we show that an isotopic Mooney-Rivlin model cannot adequately represent arterial elastin. The neo-Hookean model, with coefficient 162.57 (+/-115.44) kPa for autoclaved and 76.94 (+/-27.76) kPa for alkali-extracted samples, fits the uniaxial data better. Autoclaved elastins also sho...Continue Reading

References

May 1, 1976·Biopolymers·J A FosterC Franzblau
Jul 5, 1990·Biopolymers·M A Lillie, J M Gosline
Jan 1, 1985·Connective Tissue Research·B Starcher, S Percival
Jan 1, 1974·Journal of Ultrastructure Research·L GotteR W Horne
Apr 1, 1974·Biopolymers·C A Hoeve, P J Flory
Jan 1, 1981·Connective Tissue Research·E G ClearyI Prosser
Sep 1, 1993·The American Review of Respiratory Disease·S Q Liu, Y C Fung
Jun 27, 1998·Connective Tissue Research·M A LillieJ M Gosline
Nov 7, 1998·Computers in Biology and Medicine·G A Holzapfel, H W Weizsäcker
Jun 28, 2001·Biomaterials·W F DaamenT H Van Kuppevelt
Mar 26, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John GoslineKen Savage
May 1, 1964·Circulation Research·H WOLINSKY, S GLAGOV
Jan 1, 1994·Connective Tissue Research·M A LillieJ M Gosline

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Citations

Dec 7, 2007·Biomechanics and Modeling in Mechanobiology·P N Watton, N A Hill
Nov 9, 2010·Biomechanics and Modeling in Mechanobiology·R RezakhanihaN Stergiopulos
Oct 22, 2010·Biomechanics and Modeling in Mechanobiology·Yu Zou, Yanhang Zhang
Apr 25, 2012·Biomechanics and Modeling in Mechanobiology·Gal deBotton, Tal Oren
Jun 19, 2012·Biomechanics and Modeling in Mechanobiology·Dimitrios P Sokolis
Feb 12, 2013·Biomechanics and Modeling in Mechanobiology·Vaibhav AgrawalNamrata Gundiah
Jun 2, 2009·Annals of Biomedical Engineering·Yu Zou, Yanhang Zhang
May 13, 2014·International Journal of Non-linear Mechanics·Huan ChenGhassan Kassab
Jun 6, 2008·Journal of Biomechanical Engineering·Rana Rezakhaniha, Nikos Stergiopulos
Dec 24, 2008·Journal of Biomechanical Engineering·C A Basciano, C Kleinstreuer
Oct 17, 2009·Journal of Biomechanical Engineering·Silvia WognumMichael S Sacks
May 24, 2011·Journal of Biomechanical Engineering·Philip H KaoH Jerry Qi
Jul 1, 2012·Journal of Biomechanical Engineering·Yu Zou, Yanhang Zhang
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Steven R LammersRobin Shandas
Sep 18, 2012·The Annals of Thoracic Surgery·Sam ChitsazElaine E Tseng
Sep 20, 2011·Journal of the Mechanics and Physics of Solids·Huan ChenGhassan S Kassab
May 28, 2011·The Journal of Thoracic and Cardiovascular Surgery·Khalil KhanaferRamon Berguer
Feb 9, 2010·Ultrasonics·Asawinee DanpinidElisa E Konofagou
Apr 28, 2009·Journal of Biomechanics·Paul N WattonGerhard A Holzapfel
Oct 6, 2015·Journal of the Mechanical Behavior of Biomedical Materials·David A PrimJohn F Eberth
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Namrata GundiahLisa A Pruitt
Dec 19, 2006·Journal of Biomechanics·M A Lillie, J M Gosline
Nov 7, 2012·Journal of Biomedical Materials Research. Part a·Jungsil KimSeungik Baek
Apr 12, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Piyush GaurChristian Mayer
Apr 30, 2008·The Annals of Thoracic Surgery·Namrata GundiahElaine E Tseng
Aug 2, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Zbyněk TonarKirsti Witter
Jun 6, 2013·Journal of Biomechanics·Hannah WeisbeckerGerhard A Holzapfel
Jun 5, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Yunjie WangYanhang Zhang
Mar 30, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A DupreyR Berguer
Oct 30, 2016·Microscopy Research and Technique·Xavier García-MassóJosé L Toca-Herrera
Oct 11, 2017·Journal of Physics D: Applied Physics·Yanhang ZhangGregory S Boutis
Jan 7, 2018·Journal of Biomechanical Engineering·Yunjie WangYanhang Zhang
Mar 27, 2019·Journal of Biomechanical Engineering·Ali MadaniMohammad Mofrad
Jul 15, 2015·Biomechanics and Modeling in Mechanobiology·Arun Raina, Christian Miehe
Nov 13, 2013·Physiological Measurement·Namrata GundiahLisa A Pruitt
Apr 26, 2014·Biomedizinische Technik. Biomedical Engineering·Hans W WeizsäckerHerbert Juch
Oct 25, 2017·Scientific Reports·Barbara LynchMarie-Claire Schanne-Klein

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