Determination of substrate and product concentrations in lactic acid bacterial fermentations by proton NMR using the ERETIC method

Analytical Chemistry
V SilvestreSerge Akoka

Abstract

A 1H NMR method is described for the determination of the concentration of a chemically diverse group of metabolites over a wide concentration range in fermentation medium. The method employs the use of the ERETIC signal, which produces a pseudo-FID acquired with the FID derived from the sample components. It is shown that this signal, once calibrated against an external standard solution, can be used to determine accurately the concentration of all components present in the medium. The method is rapid, reliable, and applicable to a wide range of biological fluids. Problems such as the invisibility of certain components in the spectrum are overcome by a simple regulation of the pH.

References

Jun 1, 1975·Applied Microbiology·B E Terzaghi, W E Sandine
Jul 1, 1999·Analytical Chemistry·S AkokaM Trierweiler

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Citations

May 27, 2011·Magma·Sophie SerriereLydie Nadal-Desbarats
Apr 15, 2004·Journal of Magnetic Resonance·Nathalie Michel, Serge Akoka
Apr 6, 2005·Journal of Magnetic Resonance·Flore Le GrandSerge Akoka
Dec 7, 2002·Magnetic Resonance Imaging·F FranconiS Akoka
Nov 3, 2004·BMC Complementary and Alternative Medicine·David J Anick
Jan 5, 2011·PloS One·Kenneth I MarroMartin J Kushmerick
Nov 19, 2010·Bioanalysis·Iola F DuarteAna M Gil
Apr 2, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Roger MallolXavier Correig
Feb 2, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Franz DalitzGisela Guthausen
Sep 4, 2010·Journal of Pharmaceutical and Biomedical Analysis·Estelle MartineauSerge Akoka
Mar 26, 2010·Journal of Neuroradiology. Journal De Neuroradiologie·H DesalS Akoka
Mar 9, 2010·Journal of Pharmaceutical and Biomedical Analysis·Torgny RundlöfTorbjörn Arvidsson
Jul 4, 2008·Journal of Magnetic Resonance·Kenneth I MarroMartin J Kushmerick
Nov 25, 2011·Journal of Magnetic Resonance Imaging : JMRI·Kenneth I MarroCecil E Hayes
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Donghoon LeeMark Mathis
Aug 21, 2013·Journal of Pharmaceutical and Biomedical Analysis·Patrick GiraudeauSerge Akoka
Apr 26, 2005·Journal of Colloid and Interface Science·Valérie MolinierYves Queneau
Sep 5, 2013·Magnetic Resonance in Chemistry : MRC·Christopher H CullenChristina M Szabo
Oct 18, 2005·NMR in Biomedicine·Beathe SitterIngrid S Gribbestad
Oct 3, 2006·Expert Review of Molecular Diagnostics·Natalie J Serkova, Claus U Niemann
Oct 19, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Abdul MutlibJoann Scatina
Dec 7, 2016·Magnetic Resonance in Chemistry : MRC·Tangi JézéquelSerge Akoka
Mar 22, 2014·Journal of Agricultural and Food Chemistry·Zhizhong ShiChunbao Li
Jun 23, 2005·Journal of Agricultural and Food Chemistry·Flore Le GrandSerge Akoka

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