Determination of Ten Macrolide Drugs in Environmental Water Using Molecularly Imprinted Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xuqin SongLimin He

Abstract

With the extensive application of antibiotics in livestock, their contamination of the aquatic environment has received more attention. Molecularly imprinted polymer (MIP), as an eco-friendly and durable solid-phase extraction material, has shown great potential for the separation and enrichment of antibiotics in water. This study aims at developing a practical and economical method based on molecularly imprinted solid phase extraction (MISPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneously detecting ten macrolide drugs in different sources of water samples. The MIP was synthesized by bulk polymerization using tylosin as the template and methacrylic acid as the functional monomer. The MIP exhibited a favorable load-bearing capacity for water (>90 mL), which is more than triple that of non-molecularly imprinted polymers (NIP). The mean recoveries of macrolides at four spiked concentration levels (limit of quantification, 40, 100, and 400 ng/L) were 62.6⁻100.9%, with intra-day and inter-day relative standard deviations below 12.6%. The limit of detection and limit of quantification were 1.0⁻15.0 ng/L and 3.0⁻40.0 ng/L, respectively. Finally, the proposed method was successfully applied t...Continue Reading

References

Dec 25, 2007·Analytica Chimica Acta·Elena V PiletskaSergey A Piletsky
Mar 11, 2011·Bioscience, Biotechnology, and Biochemistry·Zhong-Lan ShenYan-Ming Liu
Jul 13, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·R GibsonC T Elliott
Jan 26, 2013·The Lancet Infectious Diseases·Elizabeth M H WellingtonA Prysor Williams
May 29, 2013·Environmental Microbiology·Felipe C CabelloAlejandro H Buschmann
Feb 4, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Feng-Yang HuYa-Hong Liu
Jul 8, 2015·Environmental Science and Pollution Research International·Céline Roose-Amsaleg, Anniet M Laverman
Sep 1, 2017·Journal of Pharmaceutical and Biomedical Analysis·Rosa Ana PérezJosé Luis Tadeo

❮ Previous
Next ❯

Citations

Dec 18, 2021·Journal of Separation Science·Guizhen Li, Kyung Ho Row

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.