Determination of the absolute concentrations of monoamine oxidase A and B in human tissues

Biochemical Pharmacology
A M O'CarrollK F Tipton

Abstract

The concentrations of monoamine oxidase-A and -B were determined in homogenates of human cerebral cortex, caudatus and placenta and in human platelet-rich plasma and platelet membranes by determining the specific binding of tritium-labelled pargyline. The concentrations of the two enzyme forms were similar in both human brain regions examined. Determinations of the minimum quantities of clorgyline, (-)-deprenyl, J-508 or pargyline necessary to give complete inhibition of enzyme activity was found to give overestimates of the amounts of monoamine oxidase-A and -B present due to nonspecific binding of these inhibitors.

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Citations

Aug 30, 1994·Biochemical Pharmacology·E M O'BrienK F Tipton
Feb 1, 1994·Progress in Neurobiology·M D BerryI A Paterson
Jan 1, 1991·Acta Neurologica Scandinavica. Supplementum·L Oreland
Feb 14, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Junchao TongStephen J Kish
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May 1, 2001·Current Protocols in Pharmacology·K F TiptonM Motherway
Nov 15, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Kira MergemeierMatthias Lehr
Apr 11, 2018·Journal of Neural Transmission·Keith F Tipton
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Dec 1, 2006·Current Protocols in Toxicology·Keith F TiptonMartha Motherway
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Jul 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qingcong WeiQigang Wang
Nov 18, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R Scott ObachLarry M Tremaine
Jul 12, 2002·Bioorganic & Medicinal Chemistry·Philippe BisselNeal Castagnoli

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