Determination of the dose-response relationship for intrathecal sufentanil in laboring patients

Anesthesia and Analgesia
N L HermanJ Tilton

Abstract

Multiple studies have investigated the efficacy of intrathecal opioids, particularly sufentanil, in laboring parturients. However, until the important pharmacological indices of the 50% and 95% effective doses (ED50 and ED95, respectively) are defined, reliable comparative studies among drugs at equipotent doses cannot be performed. This study was performed to establish the dose-response relationship of intrathecal sufentanil analgesia in labor. Sixty parturients presenting in active labor received intrathecal sufentanil 2.5 (n = 10), 5.0 (n = 10), 7.5 (n = 10), 10.0 (n = 10), 12.5 (n = 10), or 15.0 (n = 10) microg in a blind, randomized fashion. Patient 100-mm visual analog pain scale (VAS) scores, fetal heart rate (FHR), blood pressure, and heart rate were recorded at 0, 1, 5, 10, 15, 20, 25, and 30 min after administration of sufentanil and then again when the patient requested additional analgesia. Absolute VAS < or =25 mm was considered an analgesic success. Percent responders was used to construct a dose-response curve and calculate ED50 and ED95. The ED50 and ED95 for intrathecal sufentanil in laboring parturients were 2.6 (1.8-3.2, 95% confidence interval) and 8.9 (7.5-11.5) microg, respectively. There was a trend towar...Continue Reading

Associated Clinical Trials

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Citations

Jul 11, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C J ChengH M Tan
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