Determination of the Genetic Architecture Underlying Short Wavelength Sensitivity in Lake Malawi Cichlids

The Journal of Heredity
Sri Pratima NandamuriKaren L Carleton

Abstract

African cichlids are an exemplary system to study organismal diversity and rapid speciation. Species differ in external morphology including jaw shape and body coloration, but also differ in sensory systems including vision. All cichlids have 7 cone opsin genes with species differing broadly in which opsins are expressed. The differential opsin expression results in closely related species with substantial differences in spectral sensitivity of their photoreceptors. In this work, we take a first step in determining the genetic basis of opsin expression in cichlids. Using a second generation cross between 2 species with different opsin expression patterns, we make a conservative estimate that short wavelength opsin expression is regulated by a few loci. Genetic mapping in 96 F2 hybrids provides clear evidence of a cis-regulatory region for SWS1 opsin that explains 34% of the variation in expression between the 2 species. Additionally, in situ hybridization has shown that SWS1 and SWS2B opsins are coexpressed in individual single cones in the retinas of F2 progeny. Results from this work will contribute to a better understanding of the genetic architecture underlying opsin expression. This knowledge will help answer long-standing...Continue Reading

References

Jan 1, 1981·Vision Research·R D Fernald
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·J ChenE Bogenmann
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R C AlbertsonT D Kocher
May 9, 2000·Methods in Enzymology·L K Barthel, P A Raymond
May 31, 2001·Molecular Ecology·P D Danley, T D Kocher
Jul 27, 2001·Molecular Biology and Evolution·K L Carleton, T D Kocher
Apr 3, 2002·Evolution; International Journal of Organic Evolution·Anna Westerbergh, John Doebley
Feb 26, 2003·Investigative Ophthalmology & Visual Science·Aimin LiCheryl M Craft
Jul 2, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Loren H RiesebergJohn M Burke
Aug 16, 2003·The Journal of Heredity·R C AlbertsonT D Kocher
May 8, 2004·Nature Reviews. Genetics·Thomas D Kocher
Feb 18, 2005·Genetics·Bo-Young LeeThomas D Kocher
Mar 18, 2005·Molecular Biology and Evolution·Tyrone C SpadyKaren L Carleton
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yong-Jin WonJody Hey
Apr 29, 2005·Evolution; International Journal of Organic Evolution·R Craig Albertson, Thomas D Kocher
Jun 7, 2005·Visual Neuroscience·Sven HalstenbergRussell D Fernald
Jul 27, 2005·Investigative Ophthalmology & Visual Science·Melanie R RobertsThomas A Reh
Jan 20, 2006·Behavioral Neuroscience·Adam P DobberfuhlCaroly A Shumway
May 25, 2006·Molecular Biology and Evolution·Tyrone C SpadyKaren L Carleton
Jul 11, 2006·Science·Hopi E HoekstraJanet P Crossland
Jul 19, 2006·Proceedings. Biological Sciences·Ole Seehausen
Mar 14, 2007·Evolution; International Journal of Organic Evolution·Molly E Cummings
Mar 21, 2007·Molecular Biology and Evolution·Martin J GennerGeorge F Turner
May 12, 2007·Evolution; International Journal of Organic Evolution·Hopi E Hoekstra, Jerry A Coyne
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Taro TsujimuraShoji Kawamura
Sep 1, 2007·Advances in Skin & Wound Care·Richard Sal Salcido
May 27, 2008·BMC Biology·Karen L CarletonEllis R Loew
Jun 12, 2008·Annual Review of Genomics and Human Genetics·Shozo Yokoyama
Sep 2, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Shaun P CollinDavid M Hunt
Nov 20, 1935·The Journal of General Physiology·G Wald
Dec 17, 2009·Vision Research·Christopher M HofmannKaren L Carleton
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Adriana D BriscoeChuan-Chin Chiao
Mar 10, 2010·Journal of Evolutionary Biology·K L CarletonJ R Ser

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Citations

Jun 16, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nidal KaragicJulián Torres-Dowdall
Jun 1, 2018·Integrative Zoology·Zachary V Johnson, Larry J Young
Oct 14, 2020·Molecular Ecology·Karen L CarletonThomas D Kocher

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