Determination of the genotype and phenotype of serum paraoxonase 1 (PON1) status in a group of agricultural and nonagricultural workers in the Coquimbo Region, Chile

Journal of Toxicology and Environmental Health. Part a
L Zúñiga-VenegasF Pancetti

Abstract

Paraoxonase 1 (PON1) is a glycosylated enzyme that is found associated with high-density lipoproteins in blood. In addition to its endogenous antioxidant role, this enzyme is also involved in hydrolysis of organophosphate (OP) pesticides in plasma. PON1 activity shows great variability in the population as a result of a polymorphism in the coding sequence that is expressed as a Glu(Q)/Arg(R) substitution at position 192 of the amino acid sequence. The aim of this study was to determine the activity levels (phenotype) and genotype of PON1 in a group of 85 agricultural workers occupationally exposed to OP pesticides and compared to 97 control subjects without occupational exposure. Allelic and genotypic frequencies of PON1Q192R polymorphism, as well as their catalytic activities, were established for the first time in a group of agricultural Chilean workers. The Q allele was more frequently represented in our studied population (approximately 60%). The Q allele is less efficient than the R allele at metabolizing chlorpyrifos (CPF), the most widely used OP pesticide in the geographical areas where samples were obtained. Further, a large interindividual variability in PON1 activity was observed, suggesting wide variation of individ...Continue Reading

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Citations

Oct 26, 2018·Toxicology·Efthimios DardiotisAristidis Tsatsakis
Aug 28, 2020·The Science of the Total Environment·María Teresa Muñoz-QuezadaVerónica Iglesias
Jul 21, 2020·Gaceta sanitaria·Liliana Zúñiga-VenegasSandra Cortés

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Methods Mentioned

BETA
nucleic acid purification
genotyping
PCR

Software Mentioned

EcoStudy
SPSS

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