PMID: 1680196Sep 1, 1991Paper

Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects

Journal of Medicinal Chemistry
J M FukutoA K Cho


The mechanism of demethylenation of (methylenedioxy)benzene (MDB), (methylenedioxy)amphetamine (MDA), and (methylenedioxy)methamphetamine (MDMA) by purified rabbit liver cytochrome P450IIB4 has been investigated by using deuterium isotope effects. A comparison of the magnitude and direction of the observed kinetic isotope effects indicates that the three compounds are demethylenated by different mechanisms. The different mechanisms of demethylenation have been proposed on the basis of comparisons of the observed biochemical isotope effects with the isotope effects from purely chemical systems.


Feb 5, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Amit S KalgutkarA Marfat
Jan 1, 1992·Critical Reviews in Toxicology·T J Monks, S S Lau
Aug 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianxiu ZhaiWansheng Chen
Jun 20, 2007·Rapid Communications in Mass Spectrometry : RCM·Lekha SlenoGérard Hopfgartner
Sep 13, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kaisa A SalminenHannu Raunio
Jan 9, 2018·Annual Review of Pharmacology and Toxicology·Arthur K Cho
Aug 9, 2017·Scientific Reports·Hisashi TakedaTomoo Hosoe
Sep 14, 2019·Biotechnology Reports·Luke RichardsSally L Gras

Related Concepts

Cytochrome P-450 Oxygenase
Microsomes, Liver
NADPH-Ferrihemoprotein Reductase
Substrate Specificity
Hydroxyl Radical

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.