PMID: 3214672Sep 1, 1988Paper

Determination of the N-acetyl metabolites of 4,4'-methylene dianiline and 4,4'-methylene-bis(2-chloroaniline) in urine

Biomedical & Environmental Mass Spectrometry
J CockerD S Davies

Abstract

A sensitive and specific gas chromatographic/mass spectrometric assay is described for the determination of N-acetyl 4,4'-methylene dianiline (N-acetyl MDA) and N-acetyl 4,4'-methylene-bis(2-chloroaniline) (N-acetyl MbOCA) in urine. The method is based on the solvent extraction of the compounds together with deuterium-labelled internal standards, the compounds being separated and detected by capillary gas chromatography/mass spectrometry as their pentafluoropropyl derivatives. The method has been applied to the detection of N-acetyl MbOCA and N-acetyl MDA in the urine of workers occupationally exposed to MbOCA and MDA. The results show that whilst N-acetyl MbOCA is a relatively minor urinary metabolite a significant proportion of MDA is excreted as the N-acetylated compound.

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Citations

Jan 1, 1995·International Archives of Occupational and Environmental Health·M DaleneP Brunmark
Jan 1, 1995·International Archives of Occupational and Environmental Health·P BrunmarkG Skarping
Jan 1, 1990·Archives of Toxicology·G Sabbioni, H G Neumann
Mar 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S A HotchkissJ Caldwell
Jun 3, 2005·Environmental Health Perspectives·Chiu-Shong LiuHong-I Chen
Jan 1, 1996·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·J CockerH K Wilson
Nov 20, 2002·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gabriele Sabbioni, Christopher R Jones
Mar 16, 2013·International Journal of Hygiene and Environmental Health·I-Shen LinSaou-Hsing Liou
Aug 12, 2008·Toxicology and Applied Pharmacology·Kan ChenTammy R Dugas
Sep 30, 2016·Occupational and Environmental Medicine·Chung-Ching WangSaou-Hsing Liou
May 1, 1992·Human & Experimental Toxicology·J W Edwards, B G Priestly
Sep 22, 2017·Chemical Research in Toxicology·Gabriele Sabbioni

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