Determination of the phenolic content and antioxidant potential of crude extracts and isolated compounds from leaves of Cordia multispicata and Tournefortia bicolor

Pharmaceutical Biology
Thiago B Correia Da SilvaLucia M Conserva

Abstract

In this work, the total phenolic content and antioxidant activity of extracts and four flavonoids isolated from leaves of two Boraginaceae species (Cordia multispicata Cham. and Tournefortia bicolor Sw.) were evaluated using Folin-Ciocalteu reagent, DPPH free radical scavenging and inhibition of peroxidation of linoleic acid by FTC method. For comparison, ascorbic acid, alpha-tocopherol and BHT were used. In general, extracts from T. bicolor (68.8 +/- 0.001 to > 1000 mg/g) showed higher phenolic content than C. multispicata (66.1 +/- 0.009 to 231 +/- 0.07 mg/g), and also scavenged radicals (IC(50) 12.8 +/- 2.5 to 437 +/- 3.5 mg/L) and inhibited lipid peroxide formation (IC(50) 51.2 +/- 2.29 to 89 +/- 0.59 mg/L). For these extracts a good correlation between the phenolic content and antioxidant activity was observed, suggesting that T. bicolor is richer in phenolic compounds and that it could serve as a new source of natural antioxidants or nutraceuticals with potential applications. Chromatographic procedures monitored by antioxidant assays afforded seven compounds, which were identified by spectral analyses (IR, MS and 1D and 2D NMR) and comparison with reported data as being trans-phytol (1), taraxerol (2), 3,7,4'-trimethoxyf...Continue Reading

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Citations

Nov 1, 2012·Indian Journal of Pharmacology·Niladri MaityPulok K Mukherjee
Mar 8, 2017·The Journal of Pharmacy and Pharmacology·Manisha J Oza, Yogesh A Kulkarni
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Daniel M GrochowskiMichał Tomczyk
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raúl Velasco-AzorsaBeatriz Hernández-Carlos

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