Determination of the presence of interleukin-6 in bile after orthotopic liver transplantation. Its role in the diagnosis of acute rejection

Annals of Surgery
Koji UmeshitaR W Busuttil

Abstract

The authors evaluated the significance of interleukin-6 (IL-6) in bile in the diagnosis of acute rejection after liver transplantation. Interleukin-6 in blood has not been shown to be useful as a marker of acute rejection in clinical liver transplantation. In a rat liver transplantation model, the authors have found that bile IL-6 levels correlated well with the severity of rejection as determined histologically, whereas kinetics of serum IL-6 differed among rats without any definite feature related to graft rejection. Fifty-one patients who underwent orthotopic liver transplantation between May 1990 and February 1991 at the University of California, Los Angeles, were included in the study. After liver transplantation, bile and blood were collected daily, and IL-6 levels were measured by the enzyme-linked immunosorbent assay. Bile IL-6 increased to 1228 +/- 317 pg/mL on the day of transplantation and decreased to 50 pg/mL or less within 48 hours. Patients who had uneventful postoperative courses had low levels of bile IL-6 throughout their hospitalization. In patients with acute rejection, bile IL-6 significantly increased (1090 +/- 990 pg/mL; p<0.05), but decreased in response to antirejection therapy. In patients who had live...Continue Reading

References

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Citations

Mar 20, 1999·Transplantation Proceedings·A MinguelaM R Alvarez-López
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xupeng GeSuchitra Sumitran-Holgersson
Dec 16, 2009·Clinical Transplantation·Markus GollingArianeb Mehrabi
Nov 11, 2010·ANZ Journal of Surgery·Gianpiero GravanteDavid Lloyd
Apr 5, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Isabel M A BrüggenwirthPaulo N Martins
Nov 29, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Xavier P D VerhelstHans van Vlierberghe

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