Determination of the relative avidity of the specific IgG antibodies in human toxocariasis

Parasite Immunology
E DziemianB Machnicka

Abstract

Human toxocariasis is a zoonosis caused by infection with larvae of the ascarid nematode Toxocara canis and, less frequently, T. cati. Our study developed a method for distinguishing distant from recent human toxocariasis by assessing the avidity of the IgG antibodies. The avidity of specific antibodies increases with time after antigen challenge and assessment of the degree of avidity can be used to discriminate between recent and distant infections. The relative avidity was measured in 150 sera from children with visceral toxocariasis and in 46 sera from children with ocular toxocariasis. The probable time of infection was estimated on the basis of the medical history and clinical syndrome. Our study showed that 94.2% of positive sera collected from patients reporting infection > 6 months ago had high IgG avidity values, confirming distant toxocariasis, whereas 25.9% of positive sera taken < 6 months after infection showed low indices of IgG avidity. Our results suggest that measurement of the specific IgG avidity may assist in discriminating between recent and distant toxocariasis. The method can be used effectively to rule out (because of high avidity) a recently acquired infection. Low avidity is less reliable in discrimin...Continue Reading

References

Apr 1, 1994·Epidemiology and Infection·R E HollimanJ D Johnson
Mar 1, 1993·The Journal of Infectious Diseases·M LappalainenK Hedman
Jun 28, 2001·Clinical and Diagnostic Laboratory Immunology·I S MarciparA J Marcipar
Aug 1, 1996·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Alessandra SensiniAttilio Mottola
Dec 31, 2002·Archives of Medical Research·Cosme Alvarado-EsquivelOliver Liesenfeld
Mar 3, 2005·Veterinary Parasitology·C BjörkmanM M McAllister
Jun 28, 2005·Gastroentérologie Clinique Et Biologique·Delphine DesboisElisabeth Dussaix
Nov 30, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·A Aguado-MartínezL M Ortega-Mora
Jan 24, 2006·Clinical and Vaccine Immunology : CVI·Janet L FoxMichael P Busch

❮ Previous
Next ❯

Citations

May 4, 2011·Parasitology Research·Petra KolbekováLibuše Kolářová
Apr 2, 2014·Acta Tropica·Marcelo A Levenhagen, Julia M Costa-Cruz
Mar 7, 2013·Archivos de cardiología de México·Adrián Bolívar-MejíaOlinda Delgado
Feb 23, 2010·Trends in Parasitology·Alice C Y LeeDwight D Bowman
Sep 15, 2009·Diagnostic Microbiology and Infectious Disease·Marianna Nascimento ManhaniJulia Maria Costa-Cruz
Oct 28, 2015·Experimental Parasitology·Vojtech BoldišKatarína Reiterová
Feb 13, 2010·Annals of Tropical Medicine and Parasitology·G Rubinsky-ElefantM U Ferreira
Jan 16, 2013·Veterinary Parasitology·J Fillaux, J-F Magnaval
Jun 28, 2011·Immunology Letters·Henrique T GonzagaJulia M Costa-Cruz
Oct 30, 2016·Experimental Parasitology·Ricardo da Silva RaposoCecília Braga Laposy
Mar 31, 2016·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Lundia Luara Cavalcante BinRogério Giuffrida
Jun 13, 2015·Clinical Microbiology Reviews·Chia-Kwung FanUrsula Barghouth
Jan 29, 2020·EcoHealth·Marta Kołodziej-SobocińskaAndrzej Zalewski
Aug 15, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ali RostamiRobin B Gasser
Feb 10, 2021·Immunity, Inflammation and Disease·Bautista-García Sandra GuadalupePonce-Macotela Martha
Aug 5, 2021·PLoS Neglected Tropical Diseases·Priscila de Oliveira AzevedoVamilton Alvares Santarém

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.