Determination of the release of PEG and HPMC from nelfilcon A daily disposable contact lenses using a novel in vitro eye model

Journal of Biomaterials Science. Polymer Edition
Chau-Minh PhanLyndon Jones

Abstract

The traditional method to measure release of components from CLs is a vial containing a static volume of PBS (phosphate buffered saline). However, this model does not simulate physiologically relevant tear volume and natural tear flow, air exposure, and mechanical rubbing. These factors can significantly impact release kinetics. We have developed an in vitro eye model (OcuFlow) that simulates these parameters. The aim of the study was to measure the release of PEG (polyethylene glycol), and HPMC (hydroxypropyl methylcellulose) from a daily disposable hydrogel contact lens material (nelfilcon A; Dailies AquaComfort PLUS; DACP;) over 24 hrs using the OcuFlow platform. The elution of PEG and HPMC from DACP lenses was analyzed using LCMS (liquid chromatography mass spectrometry). The release of all wetting agents from the lenses followed a burst release pattern, which occurred within the first 1.5 hrs (P < 0.05). The release of PEG was greater than that of HPMC (P < 0.05). The amount of PEG and HPMC released at any given time was less than 1% of the amount in the blister pack solution. Our results suggest that HPMC and PEG are rapidly released from the CL.

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Citations

Mar 1, 2019·Investigative Ophthalmology & Visual Science·Christine F WildsoetJames S Wolffsohn
Dec 14, 2019·Rapid Communications in Mass Spectrometry : RCM·Paola RizzarelliGraziella Valenti
Sep 20, 2019·Translational Vision Science & Technology·Chau-Min PhanLyndo Jones
Jun 9, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Katsuhide YamasakiLyndon Jones
Mar 7, 2021·Pharmaceutics·Chau-Minh PhanLyndon Jones
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Mark WillcoxLyndon Jones

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Software Mentioned

Genesis
Excalibur
GraphPad Prism
Arduino
OcuFlow
Statistica
GraphPad

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