PMID: 2114631Feb 1, 1990Paper

Determination of the sensitivity of tuberculosis bacteria to pyrazinamide using human macrophage culture

Pneumologie
M Salfinger, A J Crowle

Abstract

Increasing interest is being shown in the antituberculous drug pyrazinamide. An in-vitro model using cultures of human blood macrophages was tested with 8 different Mycobacterium tuberculosis trains. A good correlation was found between the susceptibility of the strains to pyrazinamide and the Kinetics in the macrophage culture.

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