PMID: 11927848Apr 3, 2002Paper

Determination of the solubility of perfluorocarbon liquids in silicone oil in vitro and in vivo

Retina
Hans HoeraufHorst Laqua

Abstract

To investigate the solubility of perfluorocarbon liquids (PFCL) in silicone oil. Forty-eight samples of silicone oil (1,300 mPas, n = 22; 5,000 mPas, n = 26) were analyzed for dissolved fluorocarbon molecules after surgical removal from patients who had initially undergone vitreoretinal surgery with (n = 41) and as control without (n = 7) the use of perfluorodecalin in headspace gas chromatography. In vitro, the solubility of three different PFCL-perfluorooctane (PFO), perfluorodecalin (PFD), and fluoromethylcyclohexane (FMCH)-in silicone oil of various viscosities was determined. The diffusion phenomena during a direct exchange were studied. In 39 of 41 silicone oil samples removed from patients who had undergone vitreoretinal surgery with the use of PFD, small amounts of dissolved perfluorocarbons could be detected. The mean value in 5,000-mPas silicone oil was 939.0 x 10-4 m/% and in 1,300-mPas silicone oil was 322.75 x10(-4) m/%. No perfluorocarbon molecules were found in seven control patients. In vitro, the following maximum solubilities in 1,000-mPas silicone oil were measured at room temperature: PFO, 3.2 m/%; PFD, 5.1 m/%; and FMCH, 10.3 m/%. The maximum values measured in 5,000-mPas silicone oil were PFO, 3.3 m/%; PFD...Continue Reading

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Citations

Nov 23, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joachim H Dresp, Dirk-Henning Menz
Jan 26, 2010·Transplantation·Heide BrandhorstDaniel Brandhorst
Feb 25, 2014·Journal français d'ophtalmologie·S Baillif, P Gastaud
Feb 27, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marc A VeckeneerJan C van Meurs
Sep 29, 2011·Journal français d'ophtalmologie·C Chiquet, G Thuret
Jun 8, 2017·Retina·Hamouda Hamdi GhorabaMohamed Amin Heikal
Mar 21, 2019·Current Eye Research·Daniel A WenzelMaximilian Schultheiss
Jul 17, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Nicolas Feltgen, Hans Hoerauf

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