Determination of the source(s) of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization. Comparison with the dexamethasone suppression test

The Journal of Clinical Endocrinology and Metabolism
B L WajchenbergJ Goldman

Abstract

To determine the source(s) of the excessive androgen production in patients with the polycystic ovary syndrome (PCOS), 12 hirsute women with PCOS underwent selective left adrenal and left ovarian venous catheterization. Blood samples were collected simultaneously for determination of cortisol, 17-hydroxy-progesterone, androstenedione (delta), testosterone (T), dehydroepiandrosterone, and dehydroepiandrosterone sulfate. The relative contributions of adrenal secretion rates of T and delta in each patient were estimated by relating their adrenal gradients to those of cortisol. From such calculations we found that in all patients the major source of androgens was the ovary (direct ovarian secretion and/or ovarian secretion of prehormones which then were converted to androgen in the peripheral circulation). After catheterization, 11 of the 12 patients underwent a 5-day dexamethasone suppression test (2 mg/day). In 7 patients studied, plasma delta and/or T levels decreased significantly. Our results indicate that in hirsutism associated with the PCOS, the predominant source of androgens is the ovaries and that glucocorticoid suppression cannot assign adrenal origin as the site of excessive androgens.

Citations

Jan 1, 1993·Archives of Dermatological Research·H Aizawa, M Niimura
Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·Bratati SinghPrakash Chandra Mohapatra
Sep 1, 1988·Journal of Steroid Biochemistry·B E Murphy
Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·P HolowniaJ W Honour
Mar 12, 2004·Metabolism: Clinical and Experimental·Marzieh SalehiLeonid Poretsky
Jan 16, 1995·The American Journal of Medicine·R S Rittmaster
Jul 12, 2002·Journal of the American Geriatrics Society·Maria Clara M PaderoTheodore C Friedman
Jul 16, 2014·Nature Reviews. Endocrinology·Channa N Jayasena, Stephen Franks
Jun 1, 1993·Journal of the American Academy of Dermatology·L C Sperling, W L Heimer
Aug 30, 2008·Clinical Endocrinology·Eric D LevensLynnette K Nieman
Nov 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Anne R CappolaLinda P Fried
Jun 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Evgenia GourgariConstantine A Stratakis
Dec 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Carlos MoranSegundo Moran
Nov 1, 1989·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J A Eden
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J DevesaJ Cabezas-Cerrato
Jan 21, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vicky ChengCharles Faiman
Apr 9, 2014·Annals of Clinical Biochemistry·John W Honour
Jun 1, 1990·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·H D Taubert, J S Dericks-Tan
Sep 1, 1988·The New England Journal of Medicine
Mar 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C Jung-HoffmannH Kuhl
Oct 27, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shalini PatlollaSravani Chiri
May 31, 2018·Archives of Sexual Behavior·Jessica C RaisanenSari M van Anders
Dec 20, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Zuwei YangHefeng Huang

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