Determination of the upper cut-off values of serum alanine aminotransferase and aspartate aminotransferase in Chinese

World Journal of Gastroenterology : WJG
Peng ZhangShu-mei He

Abstract

To determine the upper cut-off values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a Northern Chinese population. A total of 3769 subjects in Jilin Province Northeast China were stratified to determine the potential factors affecting serum ALT and AST levels. The upper cut-off values of serum ALT and AST in these subjects were determined using receiver operating characteristic analysis and their sensitivity and specificity were evaluated. Stratification analysis revealed that serum ALT and AST levels were associated with gender, alcohol consumption, serum cholesterol and triglyceride levels, and body mass index. The upper cut-off values of serum ALT and AST were 22.15 U/L and 25.35 U/L for healthy men and 22.40 U/L and 24.25 U/L for healthy women, respectively. The new cut-off values had a higher sensitivity, but a slightly lower specificity than the current standards. Our results indicate that the new upper cut-off values of serum ALT and AST are markedly lower than current standards and may be valuable for the evaluation of liver function.

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Citations

May 29, 2018·International Journal of Hepatology·Phimpha PaboribouneEric Deharo
Apr 17, 2019·Clinical Liver Disease·Zurabi Lominadze, Eric R Kallwitz

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