PMID: 9651039Jul 3, 1998Paper

Determination of the wavelength dependence of the differential pathlength factor from near-infrared pulse signals

Physics in Medicine and Biology
M KohlA Villringer

Abstract

For the calculation of changes in oxyhaemoglobin, deoxyhaemoglobin and the redox state of cytochrome-c-oxidase from attenuation data via a modified Beer-Lambert equation the wavelength dependence of the differential pathlength factor (DPF(lambda)) has to be taken into account. The DPF, i.e. the ratio of the mean optical pathlength and the physical light source-detector separation at each wavelength, determines the crosstalk between the different concentrations and is therefore essential for a sensitive detection of chromophore changes. Here a simple method is suggested to estimate the wavelength dependence of the DPF(lambda) from pulse-induced attenuation changes measured on the head of adult humans. The essence is that the DPF is the ratio of the attenuation changes over absorption coefficient changes, and that the spectral form of the pulse correlated absorption coefficient change can be assumed to be proportional to the extinction coefficient of blood. Indicators for the validity of the DPF(lambda) derived for wavelengths between 700 and 970 nm are the stability of the calculated haemoglobin and cytochrome signals with variations of the wavelength range included for their calculation and its overall agreement with the data a...Continue Reading

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Citations

Jan 27, 2004·NeuroImage·Matthias L SchroeterD Yves von Cramon
Mar 11, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·H ObrigA Villringer
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H R HeekerenA Villringer
May 25, 2005·Journal of Biomedical Optics·Stephen P Nighswander-RempelR Anthony Shaw
Nov 13, 2007·Journal of Biomedical Optics·Elizabeth M C Hillman
Jul 10, 2010·Journal of Biomedical Optics·Turgut DurduranDaniel J Licht
May 9, 2006·Magnetic Resonance Imaging·Jens SteinbrinkHellmuth Obrig
Jul 5, 2016·Frontiers in Human Neuroscience·Muhammad A KamranMyung Yung Jeong
Mar 5, 2016·The Review of Scientific Instruments·Nishanth KrishnamurthySergio Fantini
Aug 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joseph P CulverA G Yodh
Sep 5, 2003·Physics in Medicine and Biology·D A BoasJ B Mandeville
Oct 22, 2009·Laser & Photonics Reviews·Elizabeth M C Hillman, Sean A Burgess
Jun 10, 2010·Physics in Medicine and Biology·F Orihuela-EspinaG Z Yang
Jun 18, 2020·Advanced Healthcare Materials·Sara AbdollahiAdam W Feinberg
Dec 29, 2000·Physics in Medicine and Biology·M KohlU Dirnagl
Mar 30, 2001·Physics in Medicine and Biology·J SteinbrinkH Rinneberg
Jun 5, 2002·Physics in Medicine and Biology·L Martyn KlassenRavi S Menon
Nov 18, 2018·Frontiers in Human Neuroscience·Caspar KrampePeter Kenning
Jan 9, 2019·Frontiers in Neuroinformatics·Muhammad A KamranMyung-Yung Jeong
Jan 31, 2000·Optics Express·M A FranceschiniS Fantini
Nov 6, 2020·Biomedical Optics Express·Idit FederDror Fixler
Nov 3, 2020·Cerebral Cortex Communications·Kathleen M Krol, Tobias Grossmann

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