PMID: 3134482Jun 1, 1988Paper

Determination of thiamin status during protein calorie malnutrition in rats

Journal of the American College of Nutrition
S M AhmedY Itokawa

Abstract

To clarify the influence of protein calorie malnutrition (PCM) on thiamin metabolism in rats, the effects of three diets containing different amounts of protein and sucrose were evaluated by three tests in 20 young male Wistar rats equally divided into four groups. Three of the groups, the controls (group 1), those fed high protein (group 2), and one of the two groups fed a low protein diet (group 3), were fed ad libitum. A second group (group 4) on the same low protein diet was fed 40% less than that consumed by group 3, which consumed less than the controls or high protein rats because of poor appetite. The sucrose contents of the experimental diets were inversely related to the protein contents. Thiamin concentrations were determined in blood, brain, heart, liver, kidney and spleen, and in 24-hr urine and stools. Tissue transketolase activity (TTKA) was measured in brain and liver and in erythrocytes (ETKA), the latter in association with the thiamin pyrophosphate (TPP) effect. Malnutrition caused decreased 24-hr urinary thiamin excretion, decreased ETKA, with corresponding increased TPP effect and decreased TKA of brain. As tissue thiamin concentrations were not decreased, the results suggest that malnutrition causes functi...Continue Reading

References

Jan 1, 1979·The American Journal of Clinical Nutrition·C G NeumannO V Dirige
Jan 1, 1976·Bibliotheca nutritio et dieta·J C Somogyi
Aug 1, 1976·Journal of Nutritional Science and Vitaminology·J C Somogyi
May 1, 1985·The British Journal of Nutrition·B HailemariamA A Jackson
Jan 1, 1974·Journal of Nutritional Science and Vitaminology·Y ItokawaM Fujiwara
Jan 1, 1974·The American Journal of Clinical Nutrition·M S Seelig, H A Heggtveit
Aug 15, 1969·Annals of the New York Academy of Sciences·J L Caddell
Jan 1, 1984·Annals of Nutrition & Metabolism·S I Ette
Jun 30, 1961·Science·N S SCRIMSHAW, M BEHAR

Related Concepts

Brain Chemistry
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