Determination of tobacco smoke exposure by plasma cotinine levels in infants and children attending urban public hospital clinics.

Archives of Pediatrics & Adolescent Medicine
Delia D DempseyNeal L Benowitz

Abstract

OBJECTIVE To determine the prevalence of secondhand smoke (SHS) exposure among infants and young children who received preventive care at pediatric preventative care clinics associated with an urban public hospital. Cotinine, a metabolite of nicotine, has been used to study SHS exposure in population-based studies of children 3 years of age or older. DESIGN Retrospective study using a convenience sample. SETTING Urban county pediatric primary care clinics in San Francisco, California. PARTICIPANTS A total of 496 infants and children (mean [SD] age, 2.4 [1.9] years). INTERVENTIONS Discarded plasma samples (which were routinely collected for lead screening) were tested, and medical records were reviewed, for SHS exposure. MAIN OUTCOME MEASURE Secondhand smoke exposure based on cotinine plasma level and history of exposure in the medical record. RESULTS Thirteen percent of parents reported that their child was exposed to SHS, yet biochemical testing detected cotinine in 55% of samples, at a geometric mean (SD) of 0.23 (3.55) ng/mL. There were no significant sex or age differences. African American children had much higher mean cotinine levels than did Latino children (multiplicative factor change in cotinine, 6.01 ng/ml [95% Cl, 4...Continue Reading

Citations

Feb 28, 2013·Journal of Exposure Science & Environmental Epidemiology·Sharon E MurphyAnne Joseph
Sep 13, 2012·Pediatric Allergy, Immunology, and Pulmonology·Elizabeth A Nguyen, Esteban G Burchard
Oct 19, 2013·American Journal of Public Health·Anne JosephSharon Murphy
Dec 4, 2014·International Journal of Environmental Research and Public Health·Yun WangShuiyuan Xiao
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Jan 28, 2014·International Journal of Occupational Medicine and Environmental Health·Dorota JarosińskaWojciech Hanke
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Mar 17, 2018·Carcinogenesis·Bríd M Ryan
Apr 28, 2018·International Journal of Environmental Research and Public Health·Adam Gregory GavarkovsMaureen Phipps
Oct 31, 2019·Ciência & saúde coletiva·Thiago Aquino de AmorimLuiz Henrique Batista Monteiro
Feb 16, 2020·International Journal of Environmental Research and Public Health·E Melinda Mahabee-GittensGeorg E Matt
May 30, 2013·Clinical Pharmacology and Therapeutics·D A DempseyN L Benowitz
Dec 6, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Lisa M Gatzke-KoppClancy Blair
Mar 25, 2020·International Journal of Environmental Research and Public Health·Yongzhao ShaoJoan Reibman
Feb 25, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neal L BenowitzPeyton Jacob
Nov 16, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gideon St HelenNeal L Benowitz
Nov 4, 2020·Environmental Science and Pollution Research International·Homa KashaniAlireza Mesdaghinia
Nov 30, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Albert J KsinanBernard F Fuemmeler
Jun 3, 2021·International Journal of Environmental Research and Public Health·Westley L FallavollitaBernard F Fuemmeler

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