Determination of total effective vascular compliance in patients with sepsis syndrome

American Journal of Respiratory and Critical Care Medicine
F StephanJ Y Fagon

Abstract

Changes in capacitance vessels have important consequences on cardiac filling pressure and fluid volume distribution in patients with sepsis syndrome. Vascular compliance may be evaluated from the slope of the relationship between changes in total blood volume (deltaTBV) and changes in central venous pressure (deltaCVP) during acute volume expansion (450 ml of gelatin fluid over 6 min), i.e., from the deltaTBV/deltaCVP ratio. The mean ratio (ml x mm Hg-1 x kg-1) was 2.03 +/- 0.21 in control subjects, 1.43 +/- 0.25 in mechanically ventilated patients without sepsis syndrome, and 0.94 +/- 0.24 in mechanically ventilated patients with sepsis syndrome (p < 0.0001 versus the other two groups). Based on echocardiographic determinations, cardiac performance was constantly found within the normal range (cardiac output ranged from 5.6 +/- 1.2 to 6.7 +/- 2.0 L/min in nonseptic patients from 6.8 +/- 1.9 to 7.8 +/- 2.2 in septic patients). Effective compliance of the total vascular bed is therefore reduced in patients with sepsis syndrome, independently of the hemodynamic modifications due to mechanical ventilation.

References

Nov 1, 1979·Hypertension·M E SafarN P Chau
Jul 1, 1991·Critical Care Medicine·R C Bone
May 1, 1991·Chest·M E AstizM H Weil
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Apr 1, 1985·The American Journal of Physiology·C V GreenwayI R Innes
Apr 1, 1985·Journal of Applied Physiology·M R PinskyM Klain
Jan 1, 1972·Annual Review of Physiology·A C GuytonH J Granger
Mar 1, 1974·Circulation Research·J A Drees, C F Rothe
Jun 1, 1966·The American Journal of Physiology·S ChienM I Gregersen
Feb 1, 1971·Circulation Research·A A Shoukas, K Sagawa
Jun 1, 1966·The American Journal of Physiology·S ChienM I Gregersen
Oct 1, 1983·Physiological Reviews·C F Rothe
Jan 1, 1984·British Heart Journal·H IhlenE Myhre
Aug 1, 1984·Critical Care Medicine·H Ellman
Sep 1, 1964·The American Journal of Physiology·S CHIENM I GREGERSEN

❮ Previous
Next ❯

Citations

Aug 29, 2006·Current Infectious Disease Reports·Daniel De Backer
Aug 12, 2009·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·A Scott KellerOgnjen Gajic
May 6, 2014·Journal of Critical Care·Elio AntonucciSabino Scolletta
May 19, 2018·Minerva anestesiologica·Elio Antonucci

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.