Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Aleksandar StojsavljevićDragan Manojlović

Abstract

Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes. Quadratic curvilinear functions with good performances of models and the lowest detection limits were obtained for 52Cr, 66Zn, 75As, 112Cd in collision mode, and 55Mn, 59Co, 60Ni, 65Cu, 78Se in standard mode. Treatment of serum samples with aqueous solution containing nitric acid, Triton X-100 and n-butanol gave the best results. Chemometric tools were applied for discrimination of patients with hypothyroidism. All nine elements discriminated Hy group of samples with almost the same discriminating power as indicated by their higher values for this group of patients. Statistically significant correlation (p < 0.01) was observed for several elements. Results indicated clear ...Continue Reading

Citations

Dec 11, 2019·Biological Trace Element Research·Sepide TalebiGholamreza Askari
Sep 16, 2019·Environmental Science and Pollution Research International·Mahdjoube Goldani MoghadamBorhan Mansouri
Nov 9, 2019·Environmental Science and Pollution Research International·Maryam RezaeiSamaneh Nakhaee
Aug 1, 2019·Ecotoxicology and Environmental Safety·Aleksandar StojsavljevićDragan Manojlović
Nov 17, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Elsa Nielsen
Jun 11, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·E M TanvirP Nicholas Shaw

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