Determination of Toxic Metals in Little Cigar Tobacco with 'Triple Quad' ICP-MS

Journal of Analytical Toxicology
R Steven PappasClifford H Watson

Abstract

Smoking remains the leading cause of preventable death in the USA. Much of the focus on harmful and potentially harmful constituents (HPHCs) in tobacco products has been on cigarettes. Little cigars gained popularity over the last decade until tobacco taxes made cigarettes more expensive in the USA. Many little cigar brands are similar in size with cigarettes and may be smoked in a similar manner. Scant data are available on HPHC concentrations in little cigars, therefore we developed and applied a new analytical method to determine concentrations of 10 toxic metals in little cigar tobacco. The method utilizes 'triple quadrupole' ICP-MS. By optimizing octapole bias, energy discrimination and cell gas flow settings, we were able to accurately quantify a range of elements including those for which the cell gas reactions were endothermic. All standard modes (Single Quad No Gas, MS-MS NH3/He and MS-MS O2) were utilized for the quantitation of 10 toxic metals in little cigar tobacco, including uranium, which was added as an analyte in the new method. Because of the elimination of interfering ions at 'shifted analyte masses', detection limits were lower compared with a previous method. Tobacco selenium concentrations were below the l...Continue Reading

References

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Apr 4, 2013·Journal of Analytical Toxicology·Mark R FresquezClifford H Watson
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Feb 19, 2014·Journal of Analytical Toxicology·R Steven PappasClifford H Watson

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Citations

Sep 12, 2015·Journal of Analytical Toxicology·R Steven PappasClifford H Watson
Feb 7, 2017·Journal of Analytical Toxicology·Mark R FresquezR Steven Pappas
Mar 25, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Todd L CecilMatthew R Holman
Jul 2, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Amy L NymanMichael P Eriksen
Sep 30, 2017·International Journal of Environmental Research and Public Health·Patricia RichterR Steven Pappas
Dec 20, 2017·Chemistry Central Journal·K McAdamB Rodu
Oct 24, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Reema GoelJohn P Richie
Nov 22, 2018·Journal of Analytical Toxicology·Ayesha Begum MohammadMohamed Saleh Al-Hajjaj
Jan 28, 2020·Journal of Analytical Toxicology·Thalles Pedrosa LisboaRafael Arromba de Sousa
Jan 31, 2021·Environmental Science and Pollution Research International·Xing WangWeihong Chen

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