Determination of toxicity of Campylobacter jejuni isolated from humans and from poultry carcasses acquired at various stages of production

Journal of Applied Microbiology
C Gilbert, M Slavik

Abstract

The research focused on the determination of the toxicity variation associated with Campylobacter jejuni isolated from humans and chickens. Campylobacter jejuni isolates were obtained from chicken carcasses and from humans exhibiting symptoms of campylobacteriosis. Using HeLa cells as the in vitro model, toxicity was determined for each isolate. The mean toxicity level of the chicken isolates was significantly lower than that of the human isolates (P < 0.001). There was a wide range of toxicity in C. jejuni isolated from chickens and the percentage of isolates exhibiting low toxicity remaining relatively constant. All C. jejuni isolates from humans possessed either medium or high levels of toxicity. All wildtype C. jejuni isolates obtained from poultry carcasses may not be equally important as a human foodborne pathogen. Campylobacter jejuni remains a primary foodborne pathogen and increased efforts are needed to determine the impact of wildtype isolates in causing human illness. The present research indicates that all isolates may not be equally important in regards to disease potential. The information found should be included in efforts to develop C. jejuni detection, control and infection modelling.

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Citations

May 6, 2005·Journal of Clinical Microbiology·William G MillerRobert E Mandrell
May 4, 2011·Journal of Food Science·Irene HanningSteven C Ricke
Jul 17, 2013·Critical Reviews in Microbiology·Rakesh Kumar Sharma, Daljit Singh Arora
Apr 10, 2010·Journal of Food Protection·N HaddadJ-M Cappelier
Oct 20, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Elnaz OhadiGholamreza Irajian

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