Determination of Tumor Marker Carcinoembryonic Antigen with Biosensor Based on Optical Quantum Weak Measurements

Sensors
Tian GuanRui Cui

Abstract

A phase-sensitive weak measurement biosensor was proposed for the detection of carcinoembryonic antigen (CEA), one common category of tumor markers. The total internal reflection (TIR) at the interface of the prism without precious metal coating was exploited to introduce the phase delay between horizontal and vertical polarizations, which can be determined through the central wavelength shift of output spectra for the sensing of the refractive index of the sample. In the weak measurement analysis, the specific binding reaction of tumor markers with a refractive index change on the surface of the prism can be monitored in real time through the central wavelength shift. With the specific absorption measurement, the feasibility of this weak measurement-based biosensor was experimentally demonstrated. We provide a low cost and convenient approach for tumor marker detection.

References

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Apr 19, 2013·Optics Letters·G JayaswalM Merano
Dec 2, 2015·Biosensors & Bioelectronics·John H T Luong, Sandeep Kumar Vashist
Mar 21, 2017·Biosensors & Bioelectronics·Dongmei LiZhiyuan Shen
Dec 17, 2017·Biosensors & Bioelectronics·Xuefang GuHeinz-Bernhard Kraatz

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Methods Mentioned

BETA
biosensors
surface
biosensor
biosensing
surface plasmon resonance

Software Mentioned

MATLAB

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