Determination of water penetration and drug concentration profiles in HPMC-based matrix tablets by near infrared chemical imaging

Journal of Pharmaceutical Sciences
Weiyong LiDenita Winstead

Abstract

This work describes methodologies based on near infrared chemical imaging (NIR CI) and chemometric data analysis for studying hydration behaviors of prolonged release tablets, which contain a high solubility drug at high load and a hydrophilic polymer hydroxypropylmethylcellulose (HPMC). Hydration studies were performed by suspending the tablets in water at ambient temperature. The hydrated tablets were then dissected and scanned by NIR CI. Single wavelength images were obtained for accurately measuring radial dimension of the gel layer and size of the tablet core. By performing a principal component analysis (PCA), the phenomenon of polymer phase transition from the glassy state to rubbery state was detected and visualized. Partial least squares (PLS) models were created for quantitative analysis of the active pharmaceutical ingredient (API) and relative concentration of water in the hydrated tablets. The API concentration profiles are suitable for defining the swelling front in hydrated tablets. Because the NIR CI results are pixel-specific and each pixel has its unique coordinates, it is feasible to analyze and present the results according to spatial locations. The physical and chemical changes at the swelling/diffusion fro...Continue Reading

References

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Aug 1, 2000·International Journal of Pharmaceutics·C FerreroM R Jiménez-Castellanos
Jul 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Y RoggoM Ulmschneider

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Citations

Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Francesco TresJonathan C Burley
Oct 13, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Paolo AvalleAgnieszka Jastrzemska
Sep 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qilei ZhangMichael Mantle
Jun 15, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Paolo AvalleAnna Midwinter
Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina MaderueloJosé M Lanao
May 10, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fengbin YeJesper Østergaard
Mar 6, 2012·International Journal of Pharmaceutics·Jari PajanderJesper Ostergaard
Oct 22, 2016·Pharmaceutical Research·Yu Sun, Jesper Østergaard
Apr 17, 2015·Drug Testing and Analysis·Luwei ZhouYanjiang Qiao
Aug 31, 2021·Advanced Drug Delivery Reviews·Benedict BrownKofi Asare-Addo

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