Determining a magnetic resonance imaging inflammatory activity acceptable state without subsequent radiographic progression in rheumatoid arthritis: results from a followup MRI study of 254 patients in clinical remission or low disease activity

The Journal of Rheumatology
Frédérique GandjbakhchMikkel Østergaard

Abstract

To assess the predictive value of magnetic resonance imaging (MRI)-detected subclinical inflammation for subsequent radiographic progression in a longitudinal study of patients with rheumatoid arthritis (RA) in clinical remission or low disease activity (LDA), and to determine cutoffs for an MRI inflammatory activity acceptable state in RA in which radiographic progression rarely occurs. Patients with RA in clinical remission [28-joint Disease Activity Score-C-reactive protein (DAS28-CRP) < 2.6, n = 185] or LDA state (2.6 ≤ DAS28-CRP < 3.2, n = 69) with longitudinal MRI and radiographic data were included from 5 cohorts (4 international centers). MRI were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI scoring system (RAMRIS). Statistical analyses included an underlying conditional logistic regression model stratified per cohort, with radiographic progression as dependent variable. A total of 254 patients were included in the multivariate analyses. At baseline, synovitis was observed in 95% and osteitis in 49% of patients. Radiographic progression was observed in 60 patients (24%). RAMRIS synovitis was the only independent predictive factor in multivariate analysis. ROC analysis identified a cutoff v...Continue Reading

References

Jan 20, 2004·Arthritis and Rheumatism·Esmeralda T H MolenaarBen A C Dijkmans
Jan 14, 2005·Annals of the Rheumatic Diseases·P ConaghanM Østergaard
Jan 14, 2005·Annals of the Rheumatic Diseases·B EjbjergM Østergaard
Jan 14, 2005·Annals of the Rheumatic Diseases·P BirdM Østergaard
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
Jun 3, 2010·The Journal of Rheumatology·Margaret H Y MaDavid L Scott
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Jan 18, 2012·Nature Reviews. Rheumatology·Siri LillegravenEspen A Haavardsholm
Feb 2, 2012·Annals of the Rheumatic Diseases·Benazir SaleemPaul Emery

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Citations

Apr 23, 2014·Nature Reviews. Rheumatology·Mikkel Østergaard, Signe Møller-Bisgaard
Jul 2, 2015·Expert Review of Clinical Pharmacology·Hanna L GulPaul Emery
Sep 22, 2015·Expert Review of Clinical Immunology·Walter GrassiEmilio Filippucci
Dec 25, 2015·Best Practice & Research. Clinical Rheumatology·Joshua F BakerPhilip G Conaghan
Nov 29, 2015·Seminars in Arthritis and Rheumatism·Orrin M TroumCharles Peterfy
Oct 9, 2014·International Journal of Rheumatic Diseases·Takeshi SuzukiTakayuki Sumida
Dec 17, 2008·World Journal of Surgical Oncology·Naoto FukunagaYoshiyuki Fujii
Jun 21, 2015·Annals of the Rheumatic Diseases·Joshua F BakerMikkel Østergaard
Apr 7, 2009·European Journal of Radiology·Nathalie BoutryAnne Cotten
Oct 1, 2016·Rheumatology·Wouter P NieuwenhuisAnnette H M van der Helm-van Mil
Oct 12, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Eric Y ChangArthur Kavanaugh
Feb 20, 2017·Cytokine·Kensuke KoyamaKenichi Matsuda
Oct 5, 2017·Therapeutic Advances in Musculoskeletal Disease·Sofia Ajeganova, Tom Huizinga
Jul 5, 2018·Expert Review of Clinical Immunology·Clara MalattiaAlberto Martini
Aug 3, 2014·The Journal of Rheumatology·Suzanne Kafaja, Daniel E Furst
Feb 12, 2017·International Journal of Rheumatic Diseases·Marcos CerqueiraJosé A Costa
Jan 8, 2018·Pediatric Radiology·E Charlotte van GulikRobert Hemke
Dec 18, 2015·Revista brasileira de reumatologia·Lílian Santuza Santos PortoAdriana Maria Kakehasi
Mar 19, 2015·Current Opinion in Rheumatology·Daniel Aletaha
Mar 19, 2019·La Radiologia medica·Mikkel Østergaard, Mikael Boesen
Oct 1, 2019·Rheumatic Diseases Clinics of North America·Siri Lillegraven, Espen A Haavardsholm
Jun 25, 2021·Journal of Inflammation Research·Lene Terslev, Mikkel Ostergaard

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