Determining critical relative humidity by measuring air humidity in equilibrium directly

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Xiancheng ZhanChengrong Li

Abstract

A method that simply, accurately and directly determines the critical relative humidity (H(cr)) of drugs by the measurement of the relative air humidity in equilibrium with saturated solution of drugs is presented. A new pocket humidity meter with a calibrated humidity sensor has been devised. The work of the humidity meter including the sensor is described. The principle for the proposed method is more rational and much simpler than that for both conventional methods and dynamic vapour sorption (DVS) methods. Compared with conventional methods, the proposed method is simple, prompt and can save sample; compared with the DVS system, the pocket humidity meter is significantly simpler and cheaper. The H(cr) of eleven salts and drugs measured by the proposed method and conventional methods serves as a model. The results of two-tailed two samples t-test indicate that there is no significant difference between the new method and the conventional ones.

References

Apr 28, 2001·Advanced Drug Delivery Reviews·S R ByrnA W Newman
Nov 22, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lars WadsöOlle Söderman

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Citations

Oct 12, 2010·Chemical & Pharmaceutical Bulletin·Chaoqun XiangChengrong Li
Dec 22, 2011·Drug Development and Industrial Pharmacy·Lin LuoChengrong Li
Apr 20, 2013·Drug Development and Industrial Pharmacy·Xiancheng ZhanChengrong Li
Jun 7, 2013·Drug Development and Industrial Pharmacy·Hui LiChengrong Li
Dec 4, 2010·Drug Development and Industrial Pharmacy·Yingli WangLinli Li
Jul 24, 2015·Journal of Pharmaceutical Sciences·Anatoly G Tereshchenko

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