Determining optimal clinical target volume margins in high-grade glioma based on microscopic tumor extension and magnetic resonance imaging.

Radiation Oncology
Shulun NieMan Hu

Abstract

In this study, we performed a consecutive macropathologic analysis to assess microscopic extension (ME) in high-grade glioma (HGG) to determine appropriate clinical target volume (CTV) margins for radiotherapy. The study included HGG patients with tumors located in non-functional areas, and supratotal resection was performed. The ME distance from the edge of the tumor to the microscopic tumor cells surrounding brain tissue was measured. Associations between the extent of ME and clinicopathological characteristics were evaluated by multivariate linear regression (MVLR) analysis. An ME predictive model was developed based on the MVLR model. Between June 2017 and July 2019, 652 pathologic slides obtained from 30 HGG patients were analyzed. The mean ME distance was 1.70 cm (range, 0.63 to 2.87 cm). The MVLR analysis identified that pathologic grade, subventricular zone (SVZ) contact and O6-methylguanine-DNA methyltransferase (MGMT) methylation, isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion status were independent variables predicting ME (all P < 0.05). A multivariable prediction model was developed as follows: YME = 0.672 + 0.513XGrade + 0.380XSVZ + 0.439XMGMT + 0.320XIDH + 0.333X1p/19q. The R-square value of goodn...Continue Reading

References

Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·K E WallnerM G Malkin
Sep 8, 2001·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·H AydinH von Lieven
Feb 20, 2007·International Journal of Radiation Oncology, Biology, Physics·Eric L ChangMoshe H Maor
Nov 28, 2007·Annual Review of Pathology·David N Louis
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
Sep 22, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Sep 25, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Manabu KinoshitaToshiki Yoshimine
May 16, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·G A WhitfieldA Jackson
Jun 21, 2014·Nature Reviews. Neuroscience·Vishnu Anand CuddapahHarald Sontheimer
Sep 16, 2014·International Journal of Radiation Oncology, Biology, Physics·Sebastian AdebergStephanie E Combs
May 7, 2015·Acta Neuropathologica·Kenneth AldapeAndreas von Deimling
Aug 16, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Linda ChenKristin Redmond
Jan 19, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maximilian NiyaziClaus Belka
Mar 16, 2017·The New England Journal of Medicine·James R PerryUNKNOWN Trial Investigators
Apr 8, 2017·Nature Reviews. Neurology·Karl-Josef LangenNadim Jon Shah
Aug 24, 2017·International Journal of Health Geographics·Philippe ApparicioÉric Robitaille

❮ Previous
Next ❯

Software Mentioned

TissueFAXS
3D
SPSS
DOCTOR
Photoshop

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved