Determining optimal poststroke exercise: Study protocol for a randomized controlled trial investigating therapeutic intensity and dose on functional recovery during stroke inpatient rehabilitation

International Journal of Stroke : Official Journal of the International Stroke Society
Tara D KlassenJanice J Eng

Abstract

A top priority in stroke rehabilitation research is determining the appropriate exercise dose to optimize recovery. Although more intensive rehabilitation very early after stroke may be deleterious to recovery, inpatient rehabilitation, occurring after acute care, may be a more appropriate setting to assess therapeutic dose on neurological recovery. Individuals receiving higher intensity and dose exercise programs will yield greater improvements in walking ability over usual inpatient physical therapy care. Seventy-five individuals across seven inpatient rehabilitation sites in Canada will be randomized into one of three treatment programs, each 5 days/week, for four weeks and monitored for exertion (heart rate) and repetitions (step count). The primary outcome measure is the 6 min walk and secondary outcomes include functional independence, cognitive, and quality-of-life measures. Outcome data will be assessed at four time points. This trial will contribute to our knowledge of the therapeutic intensity and dose necessary to maximize functional recovery at a very important stage of rehabilitation and neural recovery poststroke.

Associated Clinical Trials

References

Sep 12, 2001·Archives of Physical Medicine and Rehabilitation·N M SalbachC L Richards
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeff BiernaskieDale Corbett
Jan 29, 2005·Stroke; a Journal of Cerebral Circulation·Linda S WilliamsKurt Kroenke
May 16, 2006·Journal of the American Geriatrics Society·Subashan PereraStephanie A Studenski
Feb 3, 2007·Archives of Physical Medicine and Rehabilitation·Sandra ZinnH Scott Swartzwelder
Oct 3, 2007·Archives of Physical Medicine and Rehabilitation·Jan MehrholzMarcus Pohl
Dec 1, 2007·Archives of Physical Medicine and Rehabilitation·Suzie MudgeSharon E Walt
Feb 23, 2008·Physical Therapy·Lisa Blum, Nicol Korner-Bitensky
Jun 24, 2008·Physiotherapy Theory and Practice·George D FulkSusan O'Sullivan
Sep 14, 2013·Physical Therapy·Sharon BarakUNKNOWN Locomotor Experience Applied Post-Stroke (LEAPS) Investigative Team
May 29, 2014·Stroke; a Journal of Cerebral Circulation·Keith R LohseLara A Boyd
Oct 29, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Dominik GolickiA Simon Pickard

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Citations

Aug 4, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Irving H Zucker, Timothy I Musch
Aug 20, 2020·Stroke; a Journal of Cerebral Circulation·Tara D KlassenJanice J Eng

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