Determining safe alternatives for multidrug hypersensitive patients with the alternative triple antibiotic-analgesic test

Allergologia et immunopathologia
A B OzturkA F Kalyoncu

Abstract

Drug provocation tests (DPTs) need technical equipment, staff and time. There are very few allergy centres performing DPTs in Turkey. Therefore many patients are referred to these centres. One day triple-double antibiotic or non-steroidal anti-inflammatory drug (NSAID) oral DPT for determining safe alternatives is safe, cost-effective and time saving compared to conventional one day one drug oral DPT. Our aim was to investigate the safety of antibiotic-NSAID oral DPT performed on the same day to find safe alternatives in multidrug hypersensitive patients. Forty-two patients who had been diagnosed as having both antibiotic and NSAID hypersensitivity were enrolled to the study between 15 November and 15 July 2010. The reactions were urticaria and/or angio-oedema not including laryngeal oedema for all patients. Two antibiotics-one NSAID or two NSAIDs-one antibiotic triple test have been performed on the same day to study patients (n=22), while the control group (n=20) had taken drugs on three separate days. Only two patients had positive reactions during triple test and two patients had adverse reactions; one had gastric pain, one had nausea. Three patients in the control group had positive reactions. There were no significant dif...Continue Reading

References

Apr 5, 2000·Allergy and Asthma Proceedings·R S Gruchalla
Aug 13, 2003·Allergy·W AbererUNKNOWN EAACI interest group on drug hypersensitivity
Oct 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E GomesP Demoly
Nov 11, 2008·Current Pharmaceutical Design·Philippe-Jean BousquetAntonino Romano
Aug 3, 2010·Allergologia et immunopathologia·E KurtT Pinar Eser

❮ Previous
Next ❯

Citations

Jan 15, 2014·Allergologia et immunopathologia·A Fuat Kalyoncu
Jul 6, 2017·International Journal of Molecular Sciences·Ozge SoyerBulent Enis Sekerel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.