Determining the feasibility of objective adherence measurement with blister packaging smart technology

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Hein A van OnzenoortPaul-Hugo M van der Kuy

Abstract

The results of a feasibility study of blister-pack smart technology for monitoring medication adherence are reported. Research in the area of objective therapy compliance measurement has led to the development of microprocessor-driven systems that record the time a unit dose is removed from blister packaging. One device under development is the Smart Blister-a label imprinted with event-detection circuitry that can be affixed to standard commercial blister cards. In the first trial of the device in actual clinical practice, 115 community-dwelling Dutch patients receiving valsartan maintenance therapy (160 mg once daily) were given 14-day blister packages equipped with the Smart Blister. On the return of empty blister cards to the 20 participating community pharmacies, the stored information was scanned and downloaded for data analysis and patient counseling purposes. A total of 245 Smart Blister-equipped packages were used by valsartan recipients during the eight-month study. The device was largely effective in recording patient and blister-card identification data and other desired information. However, in 17% of cases, the Smart Blister system registered multiple tablet-removal events at the same time, presumably indicating u...Continue Reading

References

Dec 1, 1990·Clinical Pharmacology and Therapeutics·P RuddD Bonduelle
Jan 1, 1997·Journal of Clinical Epidemiology·J F Steiner, A V Prochazka
May 1, 1997·Clinical Pharmacokinetics·J Urquhart
Oct 3, 2003·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Hiroshi Yamada, Mitsuyoshi Nakashima
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Sep 27, 2006·Archives of Internal Medicine·P Michael HoDavid J Magid
Jan 11, 2007·JAMA : the Journal of the American Medical Association·Jeppe N RasmussenDavid A Alter
Sep 28, 2007·European Journal of Clinical Pharmacology·Valérie SantschiMichel Burnier
Dec 20, 2007·Journal of Hypertension·Boris L G van WijkJerry Avorn
Nov 6, 2008·Expert Opinion on Drug Safety·Evangelos N LiberopoulosMoses S Elisaf
Dec 4, 2009·Expert Opinion on Pharmacotherapy·T R BatesG F Watts

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Citations

Jun 28, 2013·British Journal of Clinical Pharmacology·Thi-My-Uyen NguyenNeil Cottrell
Jun 28, 2016·The Behavior Analyst·Jesse DalleryPhilip Erb
Jul 21, 2016·CNS Drugs·Jennifer B LevinMartha Sajatovic
Mar 1, 2014·Western Journal of Nursing Research·Linda G ParkKathleen Dracup
Apr 25, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ryoji Suzuki, Takashi Hasegawa
Oct 13, 2017·The International Journal of Neuropsychopharmacology·Oloruntoba J OlubokaPierre Blier
Nov 24, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Isabelle ArnetKurt E Hersberger

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