Determining the prescription of brain injuries based on the changes of the nucleolus organizer in astrocytes

Sudebno-meditsinskaia ekspertiza
Ye E MorozovZh V Dorosheva

Abstract

The well apparent signs of the proliferative reaction and activity of the nucleolus organizer in astrocytes within the zone of injury and at its periphery are considered to be the indicators of the participation of these cells in all the phases of the inflammatory and reparative processes associated with the brain injury. The objective of the present study was the evaluation of the changes in the number of the nucleoli in the nuclei of astrocytes during the acute post-traumatic period following the craniocerebral injury. A total of 26 cases of death of the men and women at the age from 36 to 50 years caused by the craniocerebral trauma were available for the examination. The tissue samples were stained with hematoxylin and eosin, based on the use of the Perls' Prussian blue staining protocol or by means of the AgNOR staining technique. The astrocytes in the regions immediately adjacent to the sites of brain injury were shown to undergo areactive necrosis during the first hours after the damage had been inflicted. The evaluation of the changes in the astrocytes required taking into consideration the influence of autolysis on the character of the signs being identified. The increase of the number of points in the astrocytes in wh...Continue Reading

References

Dec 21, 2006·International Review of Cytology·Ivan RaskaDusan Cmarko
Nov 30, 2007·Histochemistry and Cell Biology·Valentina SirriDanièle Hernandez-Verdun
Jan 8, 2010·Neurobiology of Disease·Patrick O McGowan, Moshe Szyf
Nov 26, 2010·The Journal of Biological Chemistry·Cynthia GomesMichal Hetman
Jan 22, 2013·ACS Chemical Neuroscience·Rodrigo Andrade, Samir Haj-Dahmane
Sep 18, 2013·CNS & Neurological Disorders Drug Targets·Tomasz GosBernhard Bogerts
Nov 23, 2015·European Archives of Psychiatry and Clinical Neuroscience·Marta KrzyżanowskaTomasz Gos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.