Determining the role of microRNAs in psychiatric disorders

Nature Reviews. Neuroscience
Orna Issler, Alon Chen

Abstract

Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular miRNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain miRNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain miRNAs could become novel treatment targets for psychiatric disorders.

References

Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KarayiorgouV K Lasseter
Sep 23, 1997·Psychological Medicine·R C KesslerK S Kendler
Jun 9, 1999·The American Journal of Psychiatry·K S KendlerC A Prescott
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
May 10, 2001·American Journal of Public Health·B E MolnarR C Kessler
Feb 20, 2003·RNA·Victor AmbrosThomas Tuschl
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jun 7, 2005·Genes & Development·Po Yu ChenThomas Tuschl
Jun 24, 2005·Nature·Thimmaiah P ChendrimadaRamin Shiekhattar
Jan 5, 2006·The American Journal of Psychiatry·Kenneth S KendlerNancy L Pedersen
Nov 14, 2006·Nature Structural & Molecular Biology·Glen M BorchertBeverly L Davidson
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Jul 4, 2007·The Journal of Experimental Medicine·Anne SchaeferPaul Greengard
Sep 1, 2007·Science·Jongpil KimAsa Abeliovich
Nov 9, 2007·Neuron·Maria Chahrour, Huda Y Zoghbi
Nov 13, 2007·Nature Neuroscience·Matthew E KleinRichard H Goodman
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tigwa H DavisErik M Ullian
Jul 30, 2008·Current Opinion in Neurobiology·Natascha Bushati, Stephen M Cohen
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jannet KocerhaClaes Wahlestedt
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Aug 26, 2009·Molecular and Cellular Neurosciences·Vijay Chandrasekar, Jean-Luc Dreyer
Sep 2, 2009·Molecular Psychiatry·N J BeveridgeM J Cairns
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Nov 6, 2009·Nature Reviews. Neuroscience·Gerhard Schratt
Nov 12, 2009·Nature Reviews. Neuroscience·Stephen M EackerValina L Dawson
Jan 7, 2010·Nature Structural & Molecular Biology·Zoya S Kai, Amy E Pasquinelli
Apr 1, 2010·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
Apr 7, 2010·The Journal of Cell Biology·Keith E SzulwachPeng Jin
May 8, 2010·Current Opinion in Neurobiology·Ngan K VoRichard H Goodman
May 25, 2010·Nature Reviews. Cancer·Bríd M RyanCurtis C Harris
Jul 9, 2010·Nature·Jonathan A HollanderPaul J Kenny
Jul 10, 2010·Nucleic Acids Research·Kai WangDavid J Galas
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
Aug 3, 2010·Biological Psychiatry·Tracy L BaleEric J Nestler
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hao WuYi E Sun
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Ronald C KesslerDavid R Williams

❮ Previous
Next ❯

Citations

Oct 2, 2015·Schizophrenia Bulletin·Sohei KimotoDavid A Lewis
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Anand GururajanJohn F Cryan
Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Juan F Codocedo, Nibaldo C Inestrosa
Apr 9, 2016·Neural Plasticity·Laura Musazzi, Jordan Marrocco
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Jean-François MouilletYoel Sadovsky
Aug 19, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mallory E Bowers, Rachel Yehuda
Aug 27, 2015·Nature Neuroscience·Andrew Holmes, Alon Chen
May 18, 2016·Neuropharmacology·Anna ChiarloneManuel Guzmán
Jul 28, 2016·Pharmacology & Therapeutics·Alessia Luoni, Marco Andrea Riva
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·Akira GokoolparsadhIrina Voineagu
Nov 12, 2016·Trends in Pharmacological Sciences·Richard M O'ConnorJohn F Cryan
Nov 10, 2016·Cell Reports·Naama VolkAlon Chen
Dec 31, 2016·Epilepsia·Teresa RavizzaAlon Friedman
May 24, 2017·Nature Communications·Raffaele MazziottiTommaso Pizzorusso
Oct 10, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Eric J NestlerSchahram Akbarian
Mar 9, 2018·International Journal of Molecular Sciences·Anke HoffmannDietmar Spengler
Dec 14, 2017·Journal of Cellular Biochemistry·Jahanshir TavakolizadehHamed Mirzaei
Oct 14, 2017·Genes, Brain, and Behavior·M Engel, A Chen
Oct 14, 2017·Genes, Brain, and Behavior·C P Murphy, N Singewald
Sep 19, 2017·Anesthesia and Analgesia·Simone KrethLudwig Christian Hinske
Mar 26, 2016·World Journal of Psychiatry·Peter J Gebicke-Haerter
Feb 21, 2018·Molecular Neurobiology·Jessica MingardiAlessandro Barbon
Oct 31, 2018·The Analyst·Philip GillespieDanny O'Hare
May 19, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Gianluca BagnatoSebastiano Gangemi
Oct 27, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Ryo KimuraMasatoshi Hagiwara
Dec 4, 2015·Nature Communications·Aliza P WingoKerry J Ressler
Nov 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Santiago CuestaCecilia Flores
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Jan 10, 2020·Experimental Physiology·Giuseppe IacominoUNKNOWN IDEFICS/I.Family consortium
Jan 14, 2017·Oncotarget·Diego AndolinaRossella Ventura
Oct 23, 2019·Molecular Brain·Masatoshi NakataMasatoshi Hagiwara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.