Deterministic and Stochastic Rules of Branching Govern Dendrite Morphogenesis of Sensory Neurons.

Current Biology : CB
Amrutha PalavalliThomas Lecuit

Abstract

Dendrite morphology is necessary for the correct integration of inputs that neurons receive. The branching mechanisms allowing neurons to acquire their type-specific morphology remain unclear. Classically, axon and dendrite patterns were shown to be guided by molecules, providing deterministic cues. However, the extent to which deterministic and stochastic mechanisms, based upon purely statistical bias, contribute to the emergence of dendrite shape is largely unknown. We address this issue using the Drosophila class I vpda multi-dendritic neurons. Detailed quantitative analysis of vpda dendrite morphogenesis indicates that the primary branch grows very robustly in a fixed direction, though secondary branch numbers and lengths showed fluctuations characteristic of stochastic systems. Live-tracking dendrites and computational modeling revealed how neuron shape emerges from few local statistical parameters of branch dynamics. We report key opposing aspects of how tree architecture feedbacks on the local probability of branch shrinkage. Child branches promote stabilization of parent branches, although self-repulsion promotes shrinkage. Finally, we show that self-repulsion, mediated by the adhesion molecule Dscam1, indirectly patter...Continue Reading

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Citations

Jan 24, 2021·Nature Reviews. Molecular Cell Biology·Claudio Collinet, Thomas Lecuit
Jun 8, 2021·Seminars in Cell & Developmental Biology·Giulia Paci, Yanlan Mao
Jun 17, 2021·Current Opinion in Neurobiology·Gaia Tavosanis

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