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Deterministic mutation rate variation in the human genome

Genome Research

Sep 1, 2002

Nick G C SmithHans Ellegren

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Abstract

Several studies of substitution rate variation have indicated that the local mutation rate varies over the mammalian genome. In the present study, we show significant variation in substitution rates within the noncoding part of the human genome using 4.7 Mb of human-chimpanzee pairwise ...read more

Mentioned in this Paper

Amino Acid Substitution
Mutation Abnormality
Pan troglodytes
Selection, Genetic
Pan Genus
GC Rich Sequence
Determination, Sequence Homology
Base Pairing
Variation (Genetics)
Genome, Human
1
66
1
Paper Details
References
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  • Citations67
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  • References23
  • Citations67
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Deterministic mutation rate variation in the human genome

Genome Research

Sep 1, 2002

Nick G C SmithHans Ellegren

PMID: 12213772

DOI: 10.1101/gr.220502

Abstract

Several studies of substitution rate variation have indicated that the local mutation rate varies over the mammalian genome. In the present study, we show significant variation in substitution rates within the noncoding part of the human genome using 4.7 Mb of human-chimpanzee pairwise ...read more

Mentioned in this Paper

Amino Acid Substitution
Mutation Abnormality
Pan troglodytes
Selection, Genetic
Pan Genus
1
66
1

Related Papers

Paper Details
References
  • References23
  • Citations67
123
  • References23
  • Citations67
12345...

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