Detoxification and antioxidant responses in diverse organs of Jenynsia multidentata experimentally exposed to 1,2- and 1,4-dichlorobenzene

Environmental Toxicology
Magdalena V MonferránDaniel Alberto Wunderlin

Abstract

We report changes in activities of detoxification and antioxidant enzymes as well as lipid peroxidation levels in liver, gills, and brain of Jenynsia multidentata exposed to 1,2- and 1,4-dichlorobenzene (DCB). Fish were captured at an unpolluted area, transported to the laboratory, and acclimated previous to experiments. Exposures were carried out using 1,2-DCB at 0.5, 1, 5, and 10 mg L(-1) and 1,4-DCB at 0.05, 0.1, 1, and 5 mg L(-1). After 24-h exposure, fish were sacrificed and dissected separating liver, gills, and brain of each fish. Organs were used for enzyme extractions, evaluating antioxidant system through the assay of glutathione reductase, guaiacol peroxidase, glutathione peroxidase, catalase as well as detoxification system by measuring glutathione-S-transferase (GST) activity. Additionally, thiobarbituric acid reactive substances (TBARS) method was used to evaluate the peroxidation of lipids. No changes in GST activity were found in liver of fish exposed to DCBs but in gills and brain of exposed fish. The detoxification system was activated at lower concentrations of 1,2-DCB than 1,4-DCB. Antioxidant response is activated in liver at low DCB concentrations, followed by a drop at highest levels. We also found activa...Continue Reading

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Citations

Aug 14, 2012·Archives of Environmental Contamination and Toxicology·Tamara MaggioniMaría Valeria Amé
Nov 6, 2009·Biological Trace Element Research·Wang SuhuaMichael Aschner
Dec 15, 2010·Journal of Environmental Monitoring : JEM·Magdalena Victoria MonferránDaniel Alberto Wunderlin
Aug 15, 2021·The Science of the Total Environment·Julieta PelusoCarolina M Aronzon

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