Detoxification Genes Differ Between Cactus-, Fruit-, and Flower-Feeding Drosophila

The Journal of Heredity
Rahul V RaneJohn G Oakeshott

Abstract

We use annotated genomes of 14 Drosophila species covering diverse host use phenotypes to test whether 4 gene families that often have detoxification functions are associated with host shifts among species. Bark, slime flux, flower, and generalist necrotic fruit-feeding species all have similar numbers of carboxyl/cholinesterase, glutathione S-transferase, cytochrome P450, and UDP-glucuronosyltransferase genes. However, species feeding on toxic Morinda citrifolia fruit and the fresh fruit-feeding Drosophila suzukii have about 30 and 60 more, respectively. ABC transporters show a different pattern, with the flower-feeding D. elegans and the generalist necrotic fruit and cactus feeder D. hydei having about 20 and >100 more than the other species, respectively. Surprisingly, despite the complex secondary chemistry we find that 3 cactophilic specialists in the mojavensis species cluster have variably fewer genes than any of the other species across all 4 families. We also find 82 positive selection events across the 4 families, with the terminal D. suzukii and M. citrifolia-feeding D. sechellia branches again having the highest number of such events in proportion to their respective branch lengths. Many of the genes involved in the...Continue Reading

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Citations

Sep 23, 2019·Current Opinion in Insect Science·William J Etges
Nov 8, 2019·Current Opinion in Insect Science·Andrew D GlossNoah K Whiteman
May 21, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Arina Nur FaidahChuanwang Cao

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