Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
P J FerretF Batteux

Abstract

Drug-induced acute liver failure (ALF) is a devastating and often fatal disease mainly caused by poisoning by acetaminophen (APAP). The toxic metabolite, N-acetyl-p-benzoquinone-imine (NAPQI), that leads to gluthatione depletion has been suspected to be the main effector of hepatocyte apoptosis during APAP-induced ALF. We have investigated whether reactive oxygen species (ROS) also play a role in APAP-induced ALF, and whether manganese III tetrakis (5,10,15,20 benzoic acid) (MnTBAP), a mimic of superoxide dismutase (SOD) with catalase-like activity, can treat the disease in mice. The effects of MnTBAP were tested on APAP-intoxicated mice and on isolated hepatocytes incubated with APAP. MnTBAP preventively and curatively administered significantly improved survival times, and dramatically reduced serum transaminase activity levels and parenchymal lesions in APAP-intoxicated mice. Whereas pretreatment with N-acetyl-L-cysteine (NAC) prevented ALF in a dose-dependent manner, the molecule was ineffective when curatively administered. The significant increase in glutathione peroxidase (Gpx) activity following APAP administration, and the beneficial effects of MnTBAP suggested that ROS were produced during APAP-induced ALF. A direct e...Continue Reading

Citations

Sep 29, 2005·Clinical and Experimental Nephrology·Maryam ZahmatkeshRana Ghaznavi
Jan 16, 2013·Pharmaceutical Research·Partha RoyArup Mukherjee
Mar 13, 2009·Archives of Pharmacal Research·Yung-Hsiang ChenMing-Tsung Lai
Aug 9, 2012·Archives of Pharmacal Research·Sang-Won HongSoon-Sun Hong
Oct 22, 2003·Journal of Hepatology·Sassia BeddaFrédéric Batteux
Aug 21, 2003·Toxicology Letters·Hartmut JaeschkeMary Lynn Bajt
Jul 12, 2002·Bioorganic & Medicinal Chemistry·Polivina Jolicia F GauuanBrian J Day
Aug 4, 2009·Chemical Research in Toxicology·Debra L Laskin
Jan 19, 2012·Nature Biotechnology·Suraj J PatelMartin L Yarmush
Dec 10, 2002·Antioxidants & Redox Signaling·Mark J Czaja
May 9, 2006·Journal of Gastroenterology and Hepatology·Udeme EkongJean C Emond
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Rajat Singh, Mark J Czaja
Jan 10, 2008·Artificial Organs·Ilkka IlonenHelena Isoniemi
Feb 24, 2006·Acta Pharmacologica Sinica·Irena ManovTheodore C Iancu
Jan 28, 2005·The American Journal of Chinese Medicine·H J ChaeH R Kim
Nov 11, 2011·PloS One·Romain CoriatFrédéric Batteux
Feb 8, 2014·Clinics and Research in Hepatology and Gastroenterology·Yun Chang TanJing Wang Tan
Jul 17, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y ChenV Vasiliou
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hidenari NagaiNeil Kaplowitz
Feb 13, 2003·Molecular and Cellular Endocrinology·Hui-Bao GaoMatthew P Hardy
Mar 3, 2004·Free Radical Biology & Medicine·Vuokko L Kinnula, James D Crapo
Jan 25, 2005·British Journal of Pharmacology·Heng-Cheng ChuYou-Chen Chao
May 5, 2009·European Journal of Anaesthesiology·Georgia G KostopanagiotouAgeliki Pandazi
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·Zhang-Xu Liu, Neil Kaplowitz
Jan 29, 2013·Journal of Autoimmunity·Patrick S C LeungM Eric Gershwin
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina TinelDominique Pessayre
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexis LaurentFrédéric Batteux
Aug 28, 2012·Trends in Molecular Medicine·Patrick S C LeungM Eric Gershwin
Jul 27, 2011·Environmental Toxicology and Pharmacology·Seref DemirbasMehmet Kemal Erbil
Nov 26, 2015·Toxicology Letters·Ahdab KhayyatNuran Ercal
Sep 13, 2008·Molecular Aspects of Medicine·Liyun Yuan, Neil Kaplowitz
Jul 8, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xin HuangYiyu Cheng
Aug 29, 2007·Clinics in Liver Disease·Basuki K Gunawan, Neil Kaplowitz
Jul 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick S C LeungUNKNOWN Acute Liver Failure Study Group
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian WuMark A Zern
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazuyoshi KonJohn J Lemasters
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hanh-Tu LieuLaurence Christa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Toxicological Sciences : an Official Journal of the Society of Toxicology
Tamara R KnightHartmut Jaeschke
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mohammed BourdiLance R Pohl
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D MladenovićV Todorović
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S L MichaelJ A Hinson
© 2021 Meta ULC. All rights reserved