PMID: 2124541Nov 26, 1990Paper

Detoxification of the macrolide toxin brefeldin A by Bacillus subtilis

FEBS Letters
R E KneuselK D Klöppel

Abstract

The macrolide toxin brefeldin A is a determinant of Alternaria leaf blight disease in safflower, which causes severe economic losses worldwide. Soilborne bacteria, classified as Bacillus subtilis spp., were isolated and shown to readily metabolize brefeldin A in laboratory culture to one major product. This product was identified by high resolution 2D 1H NMR and FAB mass spectroscopies as the acid resulting from hydrolysis of the macrolide ring in brefeldin A . In contrast to brefeldin A, the acid completely lacked phytotoxic activity in the standard leaf bioassay. Detoxification of brefeldin A by the lactonase activity from Bacillus subtilis may be exploited in the future to introduce resistance to Alternaria leaf blight in safflower.

References

Mar 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·V S PerkelJ A Magner
Aug 30, 1989·Biochemical and Biophysical Research Communications·K Oda, Y Nishimura
Feb 1, 1968·The Journal of Antibiotics·G TamuraK Arima
Aug 1, 1965·Experimental Cell Research·P Filner
Dec 1, 1984·The Journal of Antibiotics·P BarthélémyP Courvalin

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Citations

Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert Jan VeldmanJan Willem Kok
Apr 4, 2018·Journal of Lipid Research·Justin M SniderYusuf A Hannun

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